The Effects of Passive Heat Therapy in Patients With Chronic Kidney Disease

Virginia Commonwealth University (VCU)

Status: Completed

Conditions: Renal Insufficiency, Chronic

Treatments: Procedure: Thermoneutral Control (CON); Procedure: Whole-body Passive Heat Therapy (HT)

Study type: Interventional

Funder types: Other

Identifiers

NCT05924919

22-01741 (Other Grant/Funding Number)

HM20024906

Details and patient eligibility

About

The objective of this proposal is to investigate the acute effects of whole-body passive heat therapy using far-infrared technology on vascular function, exercise capacity, and renal function in CKD patients. The central hypothesis is that an acute bout of whole-body passive heat therapy will be well-tolerated and lead to acute improvements in large blood vessel (macrovascular) function, small blood vessel (microvascular) function, and exercise capacity without significantly altering markers of acute kidney injury.

Enrollment: 10 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion and exclusion criteria

Inclusion Criteria for participants with CKD:

• Age > 18 years old
• Stage 2-4 CKD

Exclusion Criteria for participants with CKD:

• Unstable medical conditions characterized by frequent or unpredictable biological, chemical, or psychological changes
• Uncontrolled hypertension
• Current fluid restrictions
• End stage kidney disease or currently on dialysis treatment
• Body weight < 40kg
• Exhibits any contraindications to exercise as per ACSM guidelines
• Regular tobacco and/or nicotine use
• History of heat-related illness
• Participates in regular exercise and/or sauna use
• Current hormone replacement therapy
• Pacemaker or electro-medical implant
• Persons with or at risk of intestinal disorders including gastroporesis
• History of diverticula
• Persons who have undergone surgical procedures in the GI tract
• Swallowing disorders
• Chron's disease
• Current pregnancy
• Inability to provide informed consent

Trial design

Primary purpose: Other

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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10 participants in 1 patient group

Experimental Arm: Whole-body Passive Heat Therapy (HT)

Experimental group

Description:

Heat therapy will be administered using an infrared sauna. The intervention duration will last 25 minutes at a temperature of 60°C.

Treatment:

Procedure: Whole-body Passive Heat Therapy (HT)

Procedure: Thermoneutral Control (CON)