The Effects of Peanuts and Peanut Products on Glucose Control and Vascular Function
Status and phase
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Treatments
Details and patient eligibility
About
Pilot study data have demonstrated that peanuts ameliorate the postprandial glucose and insulin response when incorporated into an acute high fat/high glucose meal. However, it is unclear whether acute consumption of peanuts can also influence vascular function. This study will therefore evaluate the effects of acute peanut consumption on vascular function, glycemic control, and plasma lipids. The hypothesis is that that addition of peanuts to a high fat/high glucose meal will reduce the production of triglycerides, glucose, and improve endothelial function as measured by flow-mediated dilation (FMD).
Enrollment
Sex
Ages
Volunteers
Inclusion criteria
- 20-50 years of age
- LDL-C below 160 mg/dL
- Triglyceride below 350 mg/dL
- Blood pressure within normal ranges (below 140/90 mmHg)
- Not taking medication for elevated lipids, blood pressure or glucose
Exclusion criteria
- Allergies to peanuts or dairy products
- Known intolerance for high fat meals
- History of cardiovascular disease (CVD), kidney disease, diabetes or inflammatory diseases such as GI disorders and arthritis
- Use of non-steroidal anti-inflammatories or immunosuppressants
- Conditions requiring the use of steroids
- Use of medication or supplements for elevated lipids, blood pressure or glucose
- Donation of blood or plasma during the study
- History of thyroid disease
- Women
- Lactose intolerance
Trial design
Primary purpose
Allocation
Interventional model
Masking
20 participants in 2 patient groups, including a placebo group
Trial contacts and locations
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Data sourced from clinicaltrials.gov
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