The Effects of Periodontal Therapy on Gingival Crevicular Fluid NLRP3,Caspase-1,IL-1β Levels in Children With Gingivitis

Aydin Adnan Menderes University

Status: Enrolling

Conditions: Gingivitis

Treatments: Procedure: Periodontal theraphy

Study type: Interventional

Funder types: Other

Identifiers

NCT06507280

2024/43

Details and patient eligibility

About

This study aims to determine the levels of NLRP3, caspase-1 and IL-1β concentrations in the gingival crevicular fluid of paediatric patients with gingivitis and their changes after periodontal treatment.

Full description

After being informed about the study and potential risks, necessary periodontal measurements will be performed and gingival crevicular fluid will be collected from all patients who gave written informed consent, and patients with gingivitis will be followed up on the 7th and 30th day after periodontal treatment.

Enrollment: 60 estimated patients

Sex: All

Ages: 11 to 14 years old

Volunteers: Accepts Healthy Volunteers

Inclusion and exclusion criteria

Inclusion Criteria:

Inclusion criteria for the group with gingivitis;

• Systemically healthy
• 11-14 years old
• Permanent dentition
• No need for endodontic and restorative treatment
• Gingivitis with gingivitis
• Have verbally and in writing agreed to participate in the study and are willing to attend follow-up appointments regularly participants will be included in the study.

Inclusion criteria for the healthy group;

• Systemically healthy
• 11-14 years old
• Permanent dentition
• No need for endodontic and restorative treatment
• Periodontally healthy
• Have verbally and in writing agreed to participate in the study and are willing to attend follow-up appointments regularly participants will be included in the study.

Exclusion Criteria

• In need of endodontic and restorative treatment
• Systemically unhealthy
• Patients who do not give verbal or written consent

Trial design

Primary purpose: Screening

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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60 participants in 2 patient groups

Gingivitis Group

Experimental group

Description:

In the first session, gingival crevicular fluid samples will be taken from teeth numbered 11,21, periodontal measurements will be made, plaques on the teeth will be cleaned and oral hygiene training will be performed. On the 7th and 30th days, gingival crevicular fluid will be taken again and periodontal measurements will be made.

Treatment:

Procedure: Periodontal theraphy

Healthy Group

No Intervention group

Description:

Gingival crevicular fluid samples will be taken from teeth numbered 11,21, periodontal measurements will be made