The Effects of Plant Bioactives on Platelet Function

Quadram Institute Bioscience

Status

Completed

Conditions

Healthy

Treatments

Other: Ex-vivo treatments with flavonoids

Study type

Interventional

Funder types

Other

Identifiers

NCT01130129

IFR02/2009

Details and patient eligibility

About

Consumption of a diet rich in fruit and vegetables is associated with a reduced risk of cardiovascular disease and the protective effect may be due to polyphenolic compounds contained within these foods. The mechanism by which polyphenols exert this effect is not clearly understood but research has focused on their potential to affect platelet function. The purpose of this study is to quantify the anti-clotting activity of a range of plant food extracts and component compounds.

Full description

A single sample of whole blood will be collected from 15 male or female volunteers aged between 18 and 65 years. After collection whole blood will be treated with a range of flavonoids to evaluate their effects on platelet function.

Enrollment

15 patients

Sex

All

Ages

18 to 65 years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

Males and females
Aged 18 - 65 years.
BMI > 19.5 and < 35
Non-smokers

Exclusion criteria

Pregnancy or have been pregnant within the last 12 months
Parallel participation in another research project which involves dietary intervention
Participation in another research project which has involved blood sampling within the last four months unless the total amount of combined blood from both studies does not exceed 470 mls.
Has donated or intends to donate blood within 16 weeks prior to during the Study period.
Depressed or elevated blood pressure measurements (<90/50 or 95/50 if symptomatic or >160/100)
Any person related to or living with any member of the study team
Diabetics
Taking regular prescribed and/or non-prescribed medication (excluding oral contraceptive and HRT).
Known bleeding disorders.