The Effects of Preoperative Aspirin on Graft Patency and Cardiac Events in Off-pump Coronary Artery Bypass

Chinese Academy of Medical Sciences, Fuwai Hospital

Status and phase: Unknown; Phase 3

Conditions: Coronary Artery Disease; Off-pump Coronary Artery Bypass; Aspirin

Treatments: Drug: aspirin

Study type: Interventional

Funder types: Other

Identifiers

NCT01268917

Fuwai Hospital 2010-259

Details and patient eligibility

About

Antiplatelet therapy is critical in the management of coronary artery disease.For patients undergoing off-pump coronary artery bypass graft,controversy remains regarding the safety of preoperative antiplatelet therapy.And there is little study about the effect of continuing aspirin until the surgery day on graft patency.So we would like to perform this study to evaluate the effects of preoperative aspirin on graft patency and cardiac events in off-pump coronary bypass.

Enrollment: 200 estimated patients

Sex: All

Ages: 18 to 85 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients undergoing elective, off-pump coronary artery bypass with at least two grafts
• patient able to give informed consent

Exclusion criteria

• on-pump CABG
• combined with the valve surgery
• Preoperative use of clopidogrel and warfarin
• allergy to aspirin
• History of severe liver disease
• History of bleeding diathesis,significant GI bleed
• Patient has known renal failure or contraindication for Cardiac CT Angio
• Redo CABG

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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200 participants in 2 patient groups

preoperative aspirin use

Experimental group

Treatment:

Drug: aspirin

Drug: aspirin

preoperative aspirin nonuse

No Intervention group

Treatment:

Drug: aspirin

Drug: aspirin