The Effects of Probiotic and HMB Supplementation on Immune and Digestive Function in Special Operations Soldiers

M

Metabolic Technologies

Status

Completed

Conditions

Military Training

Treatments

Dietary Supplement: HMB
Dietary Supplement: BC30
Dietary Supplement: Placebo

Study type

Interventional

Funder types

Other
Industry

Identifiers

NCT02762968
MTI2016-CS02

Details and patient eligibility

About

The study will determine whether acute ingestion of a probiotic combined with beta-hydroxy-beta-methylbutyrate (HMB) can enhance immune and digestive function in soldiers during 8-weeks of advanced infantry training.

Full description

Up to sixty soldiers from an elite infantry unit will perform a parallel design investigation. Soldiers will be randomly assigned to one of four groups. Group 1 will consume the probiotic plus HMB, group 2 will consume HMB only, group 3 will consume only the probiotic, and group 4 will consume only placebo. All four groups will be garrisoned together, eat the same meals, and perform the same activity. All groups will be tested before as well as after an 8-week advanced infantry training program. During each testing session resting blood samples will be obtained to assess cytokine, inflammatory, and muscle damage markers. Additionally, questionnaires will be used to determine digestive health. Anthropometric, performance, and muscle volume measures will also be assessed prior to and immediately following the supplementation and training protocol.

Enrollment

26 patients

Sex

All

Ages

18 to 30 years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

* 18 years of age * Member of the same unit of the IDF

Exclusion criteria

* Current use of dietary supplements * Current chronic use of medications

Trial design

Primary purpose

Basic Science

Allocation

Randomized

Interventional model

Parallel Assignment

Masking

Triple Blind

26 participants in 3 patient groups, including a placebo group

Placebo
Placebo Comparator group
Description:
Placebo capsules similar to the experimental treatments.
Treatment:
Dietary Supplement: Placebo
HMB
Experimental group
Description:
HMB capsules providing 3 g of calcium HMB per day.
Treatment:
Dietary Supplement: HMB
HMB + BC30
Experimental group
Description:
Capsules providing 3 g calcium HMB per day plus Bacillus Coagulans GBI-30, 6086 (BC30) mixed in water.
Treatment:
Dietary Supplement: BC30
Dietary Supplement: HMB

Trial contacts and locations

1

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Data sourced from clinicaltrials.gov

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