The Effects of Puberty and Weight on Sugar Metabolism in Children

Baylor College of Medicine

Status: Completed

Conditions: Overweight; Leanness; Adolescent

Study type: Observational

Funder types: Other

Identifiers

NCT01718080

NIH 1K126K63691

H-29652

Details and patient eligibility

About

Our goal is to investigate how hormones that control blood sugar, hunger, and stomach emptying change with puberty and being overweight. These substances change with a meal.

• For this, we need to compare lean and overweight children.
• We need to study them before and during puberty.
• All children in the study will be tested before and after a liquid meal.

Enrollment: 83 patients

Sex: All

Ages: 8 to 17 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

All groups:

Healthy lean and otherwise healthy overweight children and adolescents between the ages of 8 and 17.

Exclusion criteria

Same for all groups

The subjects will be excluded if they have:

• a history of chronic disease
• allergy to acetaminophen
• evidence or history of chemical abuse
• abnormal lab values
• pregnancy

Trial design

83 participants in 4 patient groups

Group A

Description:

Healthy lean children before puberty

Group B

Description:

Otherwise healthy overweight children before puberty

Group C

Description:

Healthy lean adolescents in mid to late puberty

Group D

Description:

Otherwise healthy overweight adolescents in mid to late puberty