The Effects Of Remote Organ Ischemic Preconditioning On Systemic Inflammatory And Glycocalyx Integrity Parameters

Acibadem University

Status: Completed

Conditions: Remote Organ Ischemic Preconditioning

Treatments: Procedure: Remote ischemic preconditioning

Study type: Interventional

Funder types: Other

Identifiers

NCT04216407

2019-01/02

Details and patient eligibility

About

Ischemia-reperfusion (IR) injury during liver transplantation is one of the major causes of mortality and morbidity associated with transplantation. Remote organ ischemic preconditioning (RIPC) is one of the most investigated practices to reduce IR injury. In this study, for the first time in the clinic, the effect of RIPC will be evaluated via both systemic inflammation parameters and also parameters showing glycocalyx integrity, on living-donor liver recipients.

Enrollment: 22 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients followed up by Acıbadem Hospital Organ Transplantation Center
• Patients accepted to participate in the study
• Older than 18 years of age
• ASA class III
• MELD score >12
• Scheduled for elective liver transplantation surgery from a living donor

Exclusion criteria

• Patients undergoing re-transplantation
• Under the age of 18 years
• Patients undergoing emergency surgery
• Patients with hepatorenal or hepatopulmonary syndrome
• Patients receiving mechanical ventilation support in the ICU
• Patients refusing to participate

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Triple Blind

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22 participants in 2 patient groups

Remote Ischemic Preconditioning

Experimental group

Description:

Short-term tourniquet on to the lower extremity before surgery

Treatment:

Procedure: Remote ischemic preconditioning

Control

No Intervention group

Description:

No intervention