The Effects of Risperidone and Olanzapine on Thinking

US Department of Veterans Affairs (VA)

Status and phase: Completed; Phase 4

Conditions: Psychotic Disorders; Schizophrenia

Treatments: Drug: Olanzapine; Drug: Risperidone

Study type: Interventional

Funder types: Other U.S. Federal agency; Industry

Identifiers

NCT00108368

MHBS-057-00S

Details and patient eligibility

About

The goal of this research is to find ways to maximize the benefits of antipsychotic medications for cognition.

Hypothesis: Risperidone and olanzapine will show greater benefits than conventional medications on assessments of social cognition, particularly affect perception and social perception.

Sex: All

Ages: 18 to 60 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Diagnosed with schizophrenia disorder by a DSM IV.
• Competent to sign informed consent
• No history of poor response to Risperdal and Zyprexa
• No organic brain disease

Exclusion criteria

• Mental retardation or any chronic medical illness which results in the patient not being appropriate for a switch to Risperdal or Zyprexa.

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Single Group Assignment

Masking: Double Blind