The Effects of Sevoflurane and Desflurane on QT Interval Measured With Cardiac Electrophysiological Balance Index

Ankara City Hospital

Status: Unknown

Conditions: QT Interval; Desflurane; Sevoflurane; Electrophysiological Balance Index

Treatments: Diagnostic Test: 12- derivation Electrocardiography

Study type: Interventional

Funder types: Other

Identifiers

NCT05225779

E1-21-2256

Details and patient eligibility

About

The primary aim of this study is to compare the effects of sevoflurane and desflurane on the QT interval. The secondary aim of this study is to compare the effects of drugs used in the induction and maintenance of anesthesia on the QT interval by calculating the Bazzet formula and iCEB.

Enrollment: 120 estimated patients

Sex: All

Ages: 18 to 65 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

1. ASA I-II-III risk group
2. the operation time is longer than 1 hour in the Urology department.

Exclusion criteria

1. bundle branch block in preoperative ECG,
2. Non-sinus heart rhythm,
3. QT length in preoperative ECG,
4. using drugs that cause known QT prolongation ( beta-blocker drugs using will be included),
5. development of malignant arrhythmia that will disrupt hemodynamics in the intraoperative period,
6. patients with electrolyte disorders,
7. patient refusal -

Trial design

Primary purpose: Diagnostic

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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120 participants in 2 patient groups

sevoflurane

Active Comparator group

Description:

General Anesthesia procedure with sevoflurane

Treatment:

Diagnostic Test: 12- derivation Electrocardiography

desflurane

Active Comparator group

Description:

General Anesthesia procedure with desflurane

Treatment:

Diagnostic Test: 12- derivation Electrocardiography