The Effects of Sevoflurane and Desflurane Used in Low-Flow Anesthesia on Thiol Disulfide Homeostasis

University of Gaziantep

Status: Completed

Conditions: Low Flow Anesthesia

Treatments: Procedure: low-flow anesthesia; Other: A 5 cc venous blood sample was obtained

Study type: Interventional

Funder types: Other

Identifiers

NCT06810453

2020/283

Details and patient eligibility

About

This study aimed to compare the effects of sevoflurane and desflurane used in low-flow anesthesia on thiol-disulfide homeostasis of patients undergoing general anesthesia.

Full description

Fifty patients were included who were scheduled to undergo elective total thyroidectomy operation under general anesthesia. The patients were assigned to one of 2 groups. Group S was the low-flow sevoflurane anesthesia group and Group D was the low-flow desflurane group. Blood samples were collected to evaluate thiol disulfide homeostasis preoperatively and postoperatively.

Enrollment: 50 patients

Sex: All

Ages: 18 to 75 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients who were scheduled to undergo elective total thyroidectomy under general anesthesia

Exclusion criteria

• Patients with diabetes mellitus, alcohol or drug addiction, smoking habits, expected difficult intubation, morbid obesity, chronic obstructive pulmonary disease, cardiovascular disease and those in pregnancy or lactation period were excluded from the study.

Trial design

Primary purpose: Other

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: Single Blind

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50 participants in 2 patient groups

sevoflurane

Other group

Description:

sevoflurane low-flow anesthesia

Treatment:

Other: A 5 cc venous blood sample was obtained

Procedure: low-flow anesthesia

desflurane

Other group

Description:

desflurane low-flow anesthesia

Treatment:

Other: A 5 cc venous blood sample was obtained

Procedure: low-flow anesthesia