Dexmedetomidine Infusion During Laparoscopic Adrenalectomy

Yonsei University

Status: Completed

Conditions: Pheochromocytoma

Treatments: Drug: dexmedetomidine; Drug: 0.9% normal saline

Study type: Interventional

Funder types: Other

Identifiers

NCT06037135

4-2012-0577

Details and patient eligibility

About

The investigators planned this study to investigate the effects of dexmedetomidine administration on intraoperative hemodynamic stability in patients with pheochromocytoma.

Enrollment: 40 patients

Sex: All

Ages: 20 to 70 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

1. ages of 20 and 70
2. American Society of Anesthesiologists(ASA) physical status classification I to III,
3. planned laparoscopic adrenalectomy for pheochromocytoma.

Exclusion criteria

1. emergency operation,
2. re-operation,
3. combined surgery with other departments,
4. body mass index (BMI) >32 kg/m2,
5. history of arrhythmias (especially AV nodal block) and ventricular conduction abnormalities,
6. uncontrolled hypertension (diastolic blood pressure >110mmHg)
7. bradycardia (heart rate < 40 beats per minute),
8. history of heart failure, hepatic and/or renal failure,
9. history of cerebrovascular disease (cerebral hemorrhage, cerebral ischemia),
10. history of beta-blocker therapy, 10) history of uncontrolled psychiatric disease.

Trial design

Primary purpose: Supportive Care

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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40 participants in 2 patient groups

dexmedetomidine group

Experimental group

Description:

In the dexmedetomidine group, dexmedetomidine is administered at a rate of 0.5 μg/kg/h immediately after anesthesia induction and continued until the completion of the surgery.

Treatment:

Drug: dexmedetomidine

Control group

Active Comparator group

Description:

In the control group, a 0.9% normal saline infusion is initiated at the same rate immediately after anesthesia induction and continued until the end of the operation.

Treatment:

Drug: 0.9% normal saline