The Effects of Sufentanil vs. Remifentanil in Total Intravenous Anesthesia With Remimazolam on Postoperative Pain

Yonsei University

Status: Enrolling

Conditions: Stomach Neoplasms

Treatments: Drug: sufentanil-remimazolam group; Drug: remifentanil-remimazolam group

Study type: Interventional

Funder types: Other

Identifiers

NCT05785234

4-2022-1606

Details and patient eligibility

About

In this study, the investigators evaluate the effect of total intravenous anesthesia using sufentanil-remimazolam and remifentanil-remimazolam on postoperative pain in patients undergoing laparoscopic gastrectomy.

Enrollment: 66 estimated patients

Sex: All

Ages: 20+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

1. 20years or older
2. Scheduled for laparoscopic-assisted gastrectomy
3. American Society of Anesthesiologists(ASA) physical status I and III

Exclusion criteria

1. Emergency operation
2. Patients with a history of severe hypersensitivity reaction to dextran 40
3. Patients who cannot use patient controlled analgesia(PCA)
4. Patients with morbid obesity [body mass index (BMI) >35 kg/m2]
5. Patients with history of uncontrolled hypertension (diastolic BP >110mmHg) or DM
6. Patients with history of heart failure (unstable angina, congestive heart failure)
7. Patients with history of liver failure, renal failure, allergic to medicine
8. Patients with history of cerebrovascular disease (cerebral hemorrhage, cerebral ischemia)
9. Patients with history of uncontrolled psychiatric disease (PTSD, anxiety, depression)
10. Patients with obstructive sleep apnea
11. Patients who cannot read the consent form (examples: Illiterate, foreigner)
12. Patients who withdraw the consent

Trial design

Primary purpose: Supportive Care

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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66 participants in 2 patient groups

Sufentanil-remimazolam group

Experimental group

Description:

The sufentanil-remimazolam group receives total intravenous anesthesia with sufentanil-remimazolam.

Treatment:

Drug: sufentanil-remimazolam group

Remifentanil-remimazolam group

Active Comparator group

Description:

The remifentanil-remimazolam group receives total intravenous anesthesia with remifentanil-remimazolam.

Treatment:

Drug: remifentanil-remimazolam group