The Effects of taVNS on Inhibitory Control

University of Electronic Science and Technology of China

Status: Completed

Conditions: Healthy

Treatments: Device: Vagus nerve stimulation via tragus; Device: Sham stimulation via earlobe

Study type: Interventional

Funder types: Other

Identifiers

NCT05468385

UESTC-neuSCAN-90

Details and patient eligibility

About

The main aim of the study is to investigate whether the transcutaneous vagus nerve stimulation(tVNS) improves the ability of inhibitory control in an emotional Go-Nogo task.

Full description

A randomized, sham-controlled, between-subject design will be employed in this study. A total of 87 healthy subjects will receive either transcutaneous vagus nerve stimulation via tragus or sham stimulation via the earlobe in the left ear. Brain activity and behavioral data for an emotional Go-Nogo task will be recorded and saliva samples will be collected before, during, and after stimulation.

Some personal traits will be assessed using different kinds of questionnaires, such as the State-Trait Anxiety Inventory (STAI), Beck's Depression Inventory(BDI), Autism Spectrum Quotient (ASQ) et al.

Enrollment: 90 patients

Sex: All

Ages: 18 to 25 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Healthy subjects without past or current psychiatric or neurological disorders

Exclusion criteria

• history of head injury;
• pregnant, menstruating, taking oral contraceptives;
• medical or psychiatric illness.

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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90 participants in 2 patient groups

Tragus stimulation

Experimental group

Description:

Vagus nerve stimulation via tragus

Treatment:

Device: Vagus nerve stimulation via tragus

Sham stimulation

Sham Comparator group

Description:

Sham stimulation via earlobe

Treatment:

Device: Sham stimulation via earlobe