The Effects of tDCS Combined With rTMS on Post-stroke Cognitive Impairment

The Second Affiliated Hospital of Dalian Medical University

Status: Enrolling

Conditions: Stroke

Treatments: Other: Non-invasive brain stimulation; Other: routine treatment

Study type: Interventional

Funder types: Other

Identifiers

NCT06252987

fnirs

Details and patient eligibility

About

If there is a comparison group: Researchers will compare [insert groups] to see if [insert effects]

The purpose of the clinical trial is to find a treatment for stroke patients with cognitive impairment, and the main questions it aims to answer are:

• [Search for effective treatments of cognitive impairment after stroke]
• [Explore brain network features with functional near-infrared spectroscopy] Participants will receive conventional treatment, tDCS treatment, or rTMS treatment, or tDCS-rTMS treatment.

And then compare cognitive function and brain function.

Enrollment: 60 estimated patients

Sex: All

Ages: 30 to 80 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Meet the clinical diagnostic criteria of the Expert Consensus on the Management of Cognitive Impairment after Stroke in 2021;
• 30-80 years old, right-handed, unilateral hemiplegia;
• Verbal expression can cooperate with the completion of the evaluation, sustained attention time is longer than 5 minutes;
• Simple Mental State Examination Scale (MMSE) score ≤26 points; MoCA scale score < 26 points; Memory test (RMBT) score less than 21 points;
• patients or their family agree to sign the informed consent;
• The Ethics Committee approved the trial.

Exclusion criteria

• Memory dysfunction caused by other diseases, such as Alzheimer's disease, lewy body dementia, pituitary tumor surgery, hypothyroidism, etc.;
• There are contraindications of rTMS and tDCS for untreated intracranial aneurysms, severe epilepsy, intracranial metal, etc.
• Patients with severe visual, cognitive or speech impairment who cannot cooperate with treatment;
• The condition is not stable; Or other serious physical diseases.

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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60 participants in 4 patient groups

common group

Sham Comparator group

Description:

routine training

Treatment:

Other: routine treatment

tDCS group

Experimental group

Description:

tDCS

Treatment:

Other: routine treatment

Other: Non-invasive brain stimulation

rTMS group

Experimental group

Description:

rTMS

Treatment:

Other: routine treatment

Other: Non-invasive brain stimulation

Combination group

Experimental group

Description:

tDCS-rTMS

Treatment:

Other: routine treatment

Other: Non-invasive brain stimulation