The Effects of the Drugs Used in Hypotensive Anaesthesia on Cochlea

TC Erciyes University

Status and phase: Completed; Phase 4

Conditions: Anesthesia; Adverse Effect; Tinnitus, Spontaneous Oto-Acoustic Emission; Reflex, Abnormal

Treatments: Drug: esmolol; Drug: Dexmedetomidine

Study type: Interventional

Funder types: Other

Identifiers

NCT02062333

2013/425

Details and patient eligibility

About

The aim of this study is to find the Effects of Anesthetics Used in Hypotensive Anesthesia on Stapes Reflex and Distortion Product Auto Acoustic Emission.

Full description

This study was aimed at evaluating the effects of dexmedetomidine and esmolol on stapes reflex and distortion product auto acoustic emission. the stapes reflex and auto acoustic emission are of considerable diagnostic significances in otolaryngology this are objective methods for the assessment of auditory function.

Enrollment: 47 patients

Sex: All

Ages: 18 to 65 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• 18-65 age
• American Society of Anaesthesiologists physical status classification (ASA)1-2
• tympanoplasty surgery
• patients with normal stapes reflexes

Exclusion criteria

• hypertension
• drug allergy
• cardiac problems
• pregnancy

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Quadruple Blind

---

47 participants in 2 patient groups

dexmedetomidine

Active Comparator group

Description:

0,4-0,8 µg./kg./h dexmedetomidine

Treatment:

Drug: Dexmedetomidine

esmolol

Active Comparator group

Description:

100- 300 µg./kg./min esmolol

Treatment:

Drug: esmolol