The Effects of Tourniquet Use in Total Knee Arthroplasty

P

Peking University

Status

Completed

Conditions

Blood Loss

Treatments

Procedure: Long-duration tourniquet
Procedure: Short-duration tourniquet

Study type

Interventional

Funder types

Other

Identifiers

NCT02429713
PekingUPH

Details and patient eligibility

About

Tourniquets are still widely used in total knee arthroplasty, but are associated with several adverse effects. Most of previous studies did not randomize the participants so the baseline difference of the patients might have influenced the outcome. Therefore, investigators conducted a randomized controlled trial, in which all the patients received staged bilateral TKA with two different durations of tourniquet use. Investigators aimed to quantify the effect of tourniquet use on reducing blood loss and to evaluate the impact of tourniquet use on functional and clinical outcome.

Full description

Fifty participants who underwent staged bilateral TKA were recruited in this study. On one side, the tourniquet was inflated immediately before incision and deflated after the hardening of the cement. On the other side the tourniquet was inflated immediately before cement application and deflated after its hardening. Blood loss, operating time, transfusion rate, postoperative pain, limb swelling, deep vein thrombosis (DVT) incidence and clinical outcomes were monitored for comparison.

Enrollment

50 patients

Sex

All

Ages

50+ years old

Volunteers

No Healthy Volunteers

Inclusion criteria

  • patients aged 50 years or over
  • classified as American Society of Anesthesiologists ASA 1-2.

Exclusion criteria

  • coagulopathy,
  • uncontrolled hypertension,
  • peripheral vascular disease and
  • patients with BMI≥35

Trial design

50 participants in 2 patient groups

Short-duration tourniquet group
Experimental group
Description:
The tourniquet was inflated immediately before cement application and deflated after its hardening
Treatment:
Procedure: Short-duration tourniquet
Long-duration tourniquet group
Active Comparator group
Description:
The tourniquet was inflated immediately before incision and deflated after the hardening of the cement
Treatment:
Procedure: Long-duration tourniquet

Trial contacts and locations

0

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Data sourced from clinicaltrials.gov

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