The Effects of Trout Fed With a Vegetable Based Feed on Cardiovascular Risk Markers and Plasma Proteome

University of Copenhagen

Status: Completed

Conditions: Cardiovascular Disease

Treatments: Behavioral: Effects of trout on CVD risk markers and plasma proteome

Study type: Interventional

Funder types: Other

Identifiers

NCT00445614

M187

Details and patient eligibility

About

Fish from the aquaculture sector constitutes an increasing part of the fish consumption in Denmark. The most important farmed fish in Denmark is the rainbow trout. Due to limited access of wild fish for the feed production, alternative feeding regimes of vegetable origin such as vegetable proteins and rapeseed oil are used instead of marine feed. This change in feeding regime may affect flesh quality and health and nutritional properties as the content of long-chain n-3 polyunsaturated fatty acids (n-3 LCPUFA) will presumably decrease in the meat. The objective of the study is to investigate the effect of vegetable based feed versus marine feed of farmed trout and its effect in healthy men on cardiovascular risk markers associated with the development of cardiovascular disease (CVD).

Full description

In a two month parallel study including 60 healthy men aged 40-70 years, the cardiovascular effect of one daily meal of trout fed with a vegetable based feed are compared with that of trout fed with marine feed (estimated intake of n-3 LCPUFA 2.6 g/day) and a standard Danish diet with poultry. Men are randomised to one of the three groups. Red blood cell fatty acid composition, classical cardiovascular disease (CVD)-risk markers (blood pressure and plasma lipid profile), newer CVD-markers (arterial compliance and plasma markers of endothelial function and inflammation) and plasma proteome analysis are measured at the beginning and end of the intervention period.

Enrollment: 72 estimated patients

Sex: Male

Ages: 40 to 70 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Age 40-70
• Body mass index 18,5 - 30

Exclusion criteria

• Exercise >10 h/week
• Chronical diseases (eg. cardiovascular and diabetes)
• Regular medication
• Fish oil supplementation
• Blood donation 2 month prior or during participation
• Above maximum recommended alcohol intake
• Blood pressure >160/100 mm Hg

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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72 participants in 3 patient groups

Marine trout

Experimental group

Description:

150 g/day of trout fed on marine based feed

Treatment:

Behavioral: Effects of trout on CVD risk markers and plasma proteome

Vegetable trout

Experimental group

Description:

150 g/d of trout fed on vegetable based feed

Treatment:

Behavioral: Effects of trout on CVD risk markers and plasma proteome

Poultry

Other group

Description:

150 g/d of poultry (for comparison)

Treatment:

Behavioral: Effects of trout on CVD risk markers and plasma proteome