The Effects of Two Different Ventilation Strategies on Lung Ventilation: An Ultrasonographic Evaluation.

Istanbul University

Status: Unknown

Conditions: Prostate Cancer

Treatments: Other: Volume Controlled Ventilation; Other: Pressure Controlled Ventilation

Study type: Interventional

Funder types: Other

Identifiers

NCT03740854

68839

Details and patient eligibility

About

This study will be performed in robotic assisted laparoscopic radical prostatectomy patients in Cerrahpasa Medical Faculty Monoblock Operating Room. Since robot-assisted laparoscopic radical prostatectomy is a surgical procedure which requires long-term mechanical ventilation, excessive trendelenburg position (30-45 °) and pneumoperitoneum; these interventions may lead to respiratory complications such as ventilation difficulty and aeration loss in patients. Nowadays, lung ultrasonography has been used in anesthesia practice and intensive care units in order to determine lung aeration loss. In this study, the investigators aimed to compare the possible aeration loss in lung parenchyma during pressure controlled ventilation and volume controlled ventilation which are frequently used in anesthesia practice in patients undergoing robotic radical prostatectomy.

Enrollment: 72 estimated patients

Sex: Male

Ages: 18 to 75 years old

Volunteers: No Healthy Volunteers

Inclusion and exclusion criteria

Inclusion Criteria: 18-75 age

• Patient who will be undergo robot assisted laparoscopic prostatectomy surgery
• Patient with ASA (American Society of Anesthesiologists) Score 1-3

Exclusion Criteria:

• Patients with ASA Score above 3
• Patients with obstructive (FEV1<%60) or restrictive pulmonary disease (FVC<%60)
• Patients with intrathoracic operation history
• Heavy smokers (>25 cigarettes/day)

Trial design

Primary purpose: Diagnostic

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Triple Blind

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72 participants in 2 patient groups

Pressure Controlled Ventilation

Active Comparator group

Description:

Patients undergoing pressure controlled ventilation

Treatment:

Other: Pressure Controlled Ventilation

Volume Controlled Ventilation

Active Comparator group

Description:

Patients undergoing volume controlled ventilation

Treatment:

Other: Volume Controlled Ventilation