The Effects of Type of Exercise in Non-alcoholic Fatty Liver Disease

M

Mahidol University

Status

Completed

Conditions

Non-alcoholic Fatty Liver Disease

Treatments

Behavioral: exercise

Study type

Interventional

Funder types

Other

Identifiers

NCT02679417
183/2558(EC1)

Details and patient eligibility

About

The type of physical activity such as, aerobic or resistant exercise required to reduce liver fat content in patient with non-alcoholic fatty liver disease (NAFLD) remains unclear. The purpose of this study is to determine whether aerobic exercise should provide improvement of hepatic fat content and inflammation as well as metabolic profiles and anthropometric parameters better than resistant exercise.

Full description

Increasing prevalence of overweight and obese worldwide, non-alcoholic fatty liver disease (NAFLD) is commonly diagnosed in daily clinical practice. Weight reduction has been the only strategy established thus far to reduce hepatic lipid levels. Thus, dietary restriction and exercise focusing on weight reduction is recommended as the cornerstone for managing NAFLD. Recent reports have indicated that increased exercise greatly reduces hepatic fat accumulation and inflammation and the related oxidative stress levels outweigh those achieved by dietary restriction alone. Clear guidelines for such a "lifestyle physical activity" for NAFLD management are currently lacking. The type of physical activity such as, aerobic or resistant exercise required to reduce liver fat content remains unclear.The purpose of this study is to determine whether aerobic exercise should provide improvement of hepatic fat content and inflammation as well as metabolic profiles and anthropometric parameters better than resistant exercise.

Enrollment

38 patients

Sex

All

Ages

18 to 60 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

  • Siriraj medical personals
  • Ultrasonography show liver steatosis by using ultrasound criteria
  • Transient elastography by using the controlled attenuation parameter show moderate degree of fatty accumulation in the liver
  • History of alcohol consumption in male <20 g/d, female <10 g/d

Exclusion criteria

  • Liver disease of other etiology
  • Medications that caused fatty accumulation in the liver
  • Treated with vitamin E or antidiabetic agents
  • Cardiopulmonary diseases or orthopedic conditions that are contraindicated for exercise

Trial design

Primary purpose

Treatment

Allocation

Randomized

Interventional model

Parallel Assignment

Masking

None (Open label)

38 participants in 2 patient groups

aerobic exercise
Active Comparator group
Description:
Each participant reach a minimum of 50 minutes of some form of aerobic exercise including running on a treadmill 5 to 7 days per week for 12 weeks under the supervision of fitness center trainers.
Treatment:
Behavioral: exercise
resistant exercise
Active Comparator group
Description:
Each participant reach a minimum of 50 minutes of some form of strength training involving repetitions of a resistance training exercise for each major muscle group at an intensity for at least 60% of a one-repetition max, 5 to 7 days per week for 12 weeks under the supervision of fitness center trainers.
Treatment:
Behavioral: exercise

Trial contacts and locations

1

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Data sourced from clinicaltrials.gov

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