The Effects of Unfiltered (Turkish) Coffee Consumption on Cardiovascular Risk Parameters

Eastern Mediterranean University

Status: Completed

Conditions: Cardiovascular Diseases

Treatments: Other: LR Coffee consumption; Other: DR Coffee consumption; Other: coffee abstention phase

Study type: Interventional

Funder types: Other

Identifiers

NCT03495336

EasternMedU

Details and patient eligibility

About

Purpose/Objective: The aim of this study is to investigate the impact of boiled unfiltered (Turkish) coffee consumption on the plasma cardiovascular risk parameters of healthy subjects. The study also explores whether two unfiltered boiled (Turkish) coffee beverages that differ in content due to different roasting degrees will differentially affect cardiovascular biomarkers.

Methods: In this crossover intervention study, healthy, nonsmoking, habitual Turkish coffee drinkers (n=28) were randomized to consume at least 3 cups of Light (LR) or Dark (DR) roast Turkish coffee brews per day for 4 weeks after a washout period (WO) of 2 weeks. Subsequent to each coffee abstinence period, both groups received the alternative intervention. After the first WO and the coffee intervention periods, anthropometric measures, blood pressure, heart rate and 13 biochemical parameters were collected and dietary records were completed.

Full description

Background: Considerable controversy exists regarding the link between coffee consumption and cardiovascular disease (CVD) risk. It has been shown that different coffee preparation and brewing methods influence the concentration of compounds present in the final coffee brew. Unlike coffee traditionally consumed in the western world, Turkish coffee is not drip filtered, but rather its method of preparation involves slowly boiling water that is mixed with thinly ground coffee beans. This style of preparation results in a greater amount of biologically active components (caffeine and diterpenes) remaining in the liquid. In addition to preparation styles, roasting process greatly affects the chemical composition of the coffee. Coffee types differing in content of major constituents differ with regard to cardiovascular health effects.

Purpose/Objective: The aim of this study is to investigate the impact of boiled unfiltered (Turkish) coffee consumption on the plasma cardiovascular risk parameters of healthy subjects. The study also explores whether two unfiltered boiled (Turkish) coffee beverages that differ in content due to different roasting degrees will differentially affect cardiovascular biomarkers.

Methods: In this crossover intervention study, healthy, nonsmoking, habitual Turkish coffee drinkers (n=28) were randomized to consume at least 3 cups of Light (LR) or Dark (DR) roast Turkish coffee brews per day for 4 weeks after a washout period (WO) of 2 weeks. Subsequent to each coffee abstinence period, both groups received the alternative intervention. After the first WO and the coffee intervention periods, anthropometric measures, blood pressure, heart rate and 13 biochemical parameters were collected and dietary records were completed.

Enrollment: 28 patients

Sex: All

Ages: 20 to 35 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Regular Turkish coffee consumer ≥ 1 cups/day
• Body mass index (BMI) 18.5-24.9 kg/m2 )
• Non-smoker or former smoker (more than a year)
• Willingness to abstain from coffee drinking
• Willingness to consume ≥ 3 cups/day of Turkish coffee

Exclusion criteria

• Acute or chronic diseases
• Severe illness with in-patient treatment during last 3 months
• Use of regular medication or any supplements
• Weight reduction ˃2 kg/week during the last month
• Pregnancy or breastfeeding
• Regular strong physical activity with ≥1h/day
• High alcohol intake a weekly intake of ˃7 units for women and ˃14units for men
• Excess consumption of total fat ˃35% of daily calories
• Consumption of saturated fatty acid ˃10% of daily calories
• Cholesterol intake ˃300mg/day

Trial design

Primary purpose: Other

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: None (Open label)

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28 participants in 4 patient groups

Washout period

Experimental group

Description:

Coffee abstention phase for 2 weeks.

Treatment:

Other: coffee abstention phase

Light roast coffee (LR)

Experimental group

Description:

Participants will follow LR Coffee consumption procedure and consume at least 3 cups of Light (LR) roast Turkish coffee brews per day for 4 weeks after a washout period (WO) of 2 weeks.

Treatment:

Other: LR Coffee consumption

Second washout period

Experimental group

Description:

coffee abstention phase for 2 weeks

Treatment:

Other: coffee abstention phase

Dark roast coffee (DR)

Experimental group

Description:

Participants will follow DR Coffee consumption procedure and consume at least 3 cups of Dark (DR) roast Turkish coffee brews per day for 4 weeks after a washout period (WO) of 2 weeks.

Treatment:

Other: DR Coffee consumption