The Effects of Vitamin E and Vitamin C and Exercise

USDA Grand Forks Human Nutrition Research Center

Status: Terminated

Conditions: Exercise and Non-exercise Effect Upon Vitamins E and C

Treatments: Dietary Supplement: Vitamin E and Vitamin C

Study type: Interventional

Funder types: Other U.S. Federal agency

Identifiers

NCT01369043

GFHNRC503

Details and patient eligibility

About

Moderate exercise is thought to be one of the best known means to improve how insulin works in people. Taking vitamin C and vitamin E is also thought to have the same effect. This study is being done to see if taking vitamin C and vitamin E improves or hinders how insulin works when people do not exercise and when they do exercise.

Full description

The objective of the study is to determine in humans whether anti-oxidant supplementation with ascorbate (vitamin C) or R,R,R-α-tocopherol acetate (vitamin E) improves insulin sensitivity in the untrained state but blocks exercise-induced increases in insulin sensitivity and other adaptations to exercise. The results will provide new information on the roles of anti-oxidant supplementation in modifying insulin sensitivity, and will inform guidelines for anti-oxidant supplementation as an adjunct to exercise.

Enrollment: 1 patient

Sex: All

Ages: 30 to 50 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• 30 to 50 years of age
• Willing to not change eating habits
• Willing to not change physical activity habits
• Willing to complete the 28 week study
• Able to swallow pills

Exclusion criteria

• smoke or use tobacco or nicotine in any form including snuff, pills, and patches
• take any medication that makes you unable to do hard exercise
• have cardiovascular, pulmonary, and/or a metabolic disease such as diabetes
• have uncontrolled high blood pressure
• have alcohol, anabolic steroids, or other substance abuse issues
• consume more than 3 alcoholic drinks/week
• have any joint or muscle injuries that affects your ability to exercise
• have cancer (other than skin cancer or carcinoma in situ of the cervix)
• are pregnant or nursing

Trial design

Primary purpose: Basic Science

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: Triple Blind

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1 participants in 2 patient groups

Vitamin E and Vitamin C

Active Comparator group

Description:

4 weeks with Vitamin E and Vitamin C supplementation with no exercise and 4 weeks of supplementation with prescribed exercise.

Treatment:

Dietary Supplement: Vitamin E and Vitamin C

Placebo

No Intervention group

Description:

Placebos instead of the Vitamin E and Vitamin C supplements