The Effects of Weight Reduction in IgA Nephropathy (WeightPro)

Chulalongkorn University

Status: Unknown

Conditions: Proteinuria

Treatments: Behavioral: weight reduction

Study type: Interventional

Funder types: Other

Identifiers

NCT01773382

PK8197

Details and patient eligibility

About

The study aims to explore the non-pharmacological treatment of IgA nephropathy by weight reduction. The investigators hypothesized that benefits of weight loss may reduce proteinuria.

Full description

This is a prospective randomized study in adult IgA nephropathy. The investigators enrolled 30 patients who have proteinuria exceeds 1 g per day with biopsy proven IgA nephropathy. The experimental arm recieves the non-pharmacological treatment, weight reduction protocol. All patients in this arm must be reduce their body weight in 3-5 % from baseline as protocol. Another arm is control group which recieves standard treatment of IgA nephropathy including ACEIs/ARBs for blood pressure control (target < 130/80 mmHg). The primary outcome is proteinuria level. The secondary outcome is cytokines and inflammatory markers level including interleukin-6, resistin, adiponectin, leptin and monocyte chemoattractant protein-1.

Enrollment: 30 estimated patients

Sex: All

Ages: 18 to 65 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Biopsy-proven IgA nephropathy
• body mass index more than 23 Kg/m2
• 24 hours urine protein more than 1 g
• estimated GFR more than 20 ml/min

Exclusion criteria

• pregnancy and lactation
• rapidly renal function decline
• crescent formation in renal biopsy more than 10%

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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30 participants in 2 patient groups

control

No Intervention group

Description:

standard treatment of IgA nephropathy including ACEI/ARB for blood pressure control (target BP \<130/80 mmHg)

weight reduction

Experimental group

Description:

target weight reduction is 3-5% from baseline

Treatment:

Behavioral: weight reduction