The Effects of Whey, Rice and Potato pRotein isOlates on appeTite rEgulatIoN in Healthy Men (PROTEIN)

University of Westminster

Status: Completed

Conditions: Appetite and General Nutritional Disorders

Treatments: Dietary Supplement: Rice protein isolate; Dietary Supplement: Whey protein isolate; Dietary Supplement: Potato protein isolate

Study type: Interventional

Funder types: Other

Identifiers

NCT04876495

VRE1516-1375

Details and patient eligibility

About

INTRODUCTION: Global protein consumption has been increasing for decades due to changes in socio-economic demographics and consumer trends towards higher protein intake, which may be related to their health benefits in performance nutrition and appetite regulation. The additional intake of protein often occurs in the form of supplements. One of the main ingredients used in sports and weight loss supplements are animal-derived proteins such as whey, which are of high quality, containing all the essential amino acids required in human nutrition with a high absorption rate. However, whey protein has a high environmental footprint, and it may contribute to insulin resistance in susceptible groups (e.g. obese, T2DM, insulin resistant, or those with sarcopenic obesity).

Rice and potato protein isolates are high-quality plant proteins containing all essential amino acids comparably to whey protein. These plant-derived proteins may provide a more sustainable and accessible alternative to animal-derived proteins for appetite regulation and weight management.

Full description

Intervention study with three treatment groups in a randomised, single-blind, triple crossover design.

Study population: Healthy male participants will receive three different isocaloric and -volumetric protein shakes prepared using whey, rice and potato protein powders on different trial days with at least a one-week washout period apart.

Biological samples (blood and saliva samples) are collected at various time points during the visit. Blood samples are collected at baseline 10 min prior (T-10), then at 30 min (T30), 60 min (T60), 120 min (T120) and at 180 min (T180) after protein shake consumption. Saliva samples are collected at baseline (T-10), then at every 30 minutes following protein shake consumption (T30, T60, T90, T120, T150, T180). In addition, pertinent questionnaires Visual Analogue Scale [VAS] for the assessment of satiety and VAS for the assessment of protein shakes' perception will be collected at T-10, T30, T60, T90, T120, T150, T180 and at T0, respectively

Enrollment: 12 patients

Sex: Male

Ages: 18 to 65 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Males (18-65 years of age)
• Healthy subjects

Exclusion criteria

• <18 years or >65 years
• Consumption of >21 units of alcohol/week
• Dieters
• Any allergies/health issues related to items being ingested
• Any serious illnesses or those on medication
• Any illness affecting taste or appetite
• Any gastrointestinal disorders
• Any eating disorders
• Any depression/mental disorders
• Smoking

Trial design

Primary purpose: Basic Science

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: Single Blind

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12 participants in 3 patient groups

Whey protein

Active Comparator group

Description:

Whey protein isolate (45.5g total protein content)

Treatment:

Dietary Supplement: Whey protein isolate

Potato protein

Active Comparator group

Description:

Potato protein isolate (45.3g total protein content)

Treatment:

Dietary Supplement: Potato protein isolate

Rice protein

Active Comparator group

Description:

Rice protein isolate (45.5g total protein content)

Treatment:

Dietary Supplement: Rice protein isolate