THE EFFETCS OF NON-SURGICAL PERIODONTAL TREATMENT ON SALIVARY BIOMARKERS OF PATIENTS WITH OSTEOPOROSIS AND PERIODONTITIS

Gazi University

Status: Completed

Conditions: Osteoporosis; Periodontitis

Treatments: Procedure: non-surgical periodontal treatment

Study type: Interventional

Funder types: Other

Identifiers

NCT04299477

2018/26120

Details and patient eligibility

About

Inflammatory mediators in periodontitis may lead to elevated systemic cytokine levels, resulting in increased bone resorption including the jaws. Osteoporosis may have an influence on the periodontal condition of post-menopausal women and the risk for periodontal disease may increase due to osteoporosis. The hypothesis of the study was that non-surgical periodontal treatment and medical treatment of osteoporosis by bisphosphonates may improve the clinical outcomes and decrease salivary levels of IL-1β, IL-17, ALP and 8-OHdG. Therefore, the aim of this study was to evaluate the mechanism of bi-directional relationship between osteoporosis and periodontal diseases and to investigate the outcomes of non-surgical periodontal treatment with regard to salivary levels of IL-1β, IL-17, 8-OHdG and ALP in patients with periodontitis and osteoporosis.

Enrollment: 75 patients

Sex: Female

Ages: 35 to 65 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• The participants were postmenopausal patients defined as absence of menstruation for at least 12 months.
• Patients with periodontitis;
• Patients who had no systemic diseases and were periodontally healthy (no attachment loss),
• Patients who were treated with oral bisphosphonate at least one year (70 mg tablet once weekly)

Exclusion criteria

• if they had received any periodontal treatment in the preceding three months,
• if they were pregnant or in the period of lactation,
• if they had systemic diseases that may interfere with normal healing mechanism,
• if they had taken antibiotics, anticonvulsants, immunosuppressants, calcium channel blockers in the preceding six months.
• Smokers

Trial design

Primary purpose: Treatment

Allocation: Non-Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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75 participants in 3 patient groups

Patients with periodontitis and osteoporosis

Experimental group

Description:

Group 1 : Patients who have periodontitis and osteoporosis prescribed with bisphosphonates

Treatment:

Procedure: non-surgical periodontal treatment

Systemically healthy patients with periodontitis

Experimental group

Description:

Group 2: Patients who have no systemic diseases but diagnosed as periodontitis

Treatment:

Procedure: non-surgical periodontal treatment

Systemically and periodontally healthy individuals

No Intervention group

Description:

Group 3: Healthy controls