The Efficacity of Hemodiafiltration Versus Hemofiltration for Renal Insufficiency During Intensive Care

Centre Hospitalier Universitaire de Nīmes

Status: Completed

Conditions: Renal Failure, Acute

Treatments: Procedure: Hemodiafiltration first; Procedure: Hemofiltration first

Study type: Interventional

Funder types: Other

Identifiers

NCT01403220

2011-A01550-41 (Other Identifier)

LOCAL/2011/PJ-02

Details and patient eligibility

About

The primary objective of this study is to compare the efficacity of hemodiafiltration and hemofiltration for decreasing plasma urea at 12h among intensive care patients. Secondary objectives include comparing urea clearance, filter duration, and %down-time, between the two techniques.

Enrollment: 163 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• According to RIFLE score, patient is stage 'F'
• The patient must be insured or beneficiary of a health insurance plan
• The patient meets at least one of the following criteria:
• metabolic acidosis (pH < 7.2), excluding keto-acidosis
• plasma urea > 25 mmol/l
• hyper-hydration is not controlled by diuretics

Exclusion criteria

• Chronic, terminal renal insufficiency with dialysis
• The patient is under judicial protection, under tutorship or curatorship
• Suspect hyperkaliemia (Kaliemia > 6.5 mmol/l with electrocardiographic effects)
• Intoxications treated via dialysis
• Pregnant, lactating, parturient women
• Medical indication for localized citrate anticoagulation
• dialysis of less than 12 h
• patient or representative refuses to participate

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: None (Open label)

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163 participants in 2 patient groups

Group 1 (hemodiafiltration first)

Active Comparator group

Description:

This group of patients will alternate consecutive dialysis sequences between hemodiafiltration and hemofiltration, but starting with hemodiafiltration.

Treatment:

Procedure: Hemodiafiltration first

Group 2 (hemofiltration first)

Active Comparator group

Description:

This group of patients will alternate consecutive dialysis sequences between hemodiafiltration and hemofiltration, but starting with hemofiltration.

Treatment:

Procedure: Hemofiltration first