The Efficacy and Safety of Beta-blockers Drugs in Adults With Spinal Hemangioma

Center for Vascular Pathology, Moscow

Status and phase: Unknown; Phase 4

Conditions: Spinal Tumor; Spinal Hemangioma; Beta Blocker Toxicity

Treatments: Drug: Atenolol Pill; Drug: Propranolol Pill

Study type: Interventional

Funder types: Other

Identifiers

NCT05106179

S_Hemangioma

Details and patient eligibility

About

Spinal hemangioma is one of the most common benign vertebral tumours. Being mostly asymptomatic, it is still associated with a pain syndrome especially if encroaches into the neural canal.

This study is organised to evaluate the efficacy and safety of β-blockers drugs in adults with spinal hemangioma.

Enrollment: 1,000 estimated patients

Sex: All

Ages: 18 to 50 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• vertebral hemangioma

Exclusion criteria

• symptomatic bradycardia
• AV block
• decompensated heart failure
• asthma

Trial design

Primary purpose: Treatment

Allocation: Non-Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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1,000 participants in 2 patient groups

Previously treated + Atenolol

Active Comparator group

Description:

The investigators suppose the outcome might be compromised if patient has been previously treated, that's why it is going to be compared to the main cohort. The results are going to be analysed separately

Treatment:

Drug: Atenolol Pill

Previously treated + Propranolol

Active Comparator group

Description:

The investigators suppose the outcome might be compromised if patient has been previously treated, that's why it is going to be compared to the main cohort. The results are going to be analysed separately

Treatment:

Drug: Propranolol Pill