The Efficacy and Safety of Platelet-rich Fibrin and Platelet Rich Plasma in Female Pattern Hair Loss Patients (PRF)

Siriraj Hospital

Status: Enrolling

Conditions: Platelet-rich Fibrin; Female Pattern Hair Loss; Platelet-Rich Plasma

Treatments: Device: Platelet rich fibrin; Device: Platelet rich plasma

Study type: Interventional

Funder types: Other

Identifiers

NCT06440655

COA no. Si286/2023

Details and patient eligibility

About

The goal of this clinical trial is to compare between platelet-rich fibrin and platelet-rich plasma in female pattern hair loss . The main question[s] it aims to answer are:

• efficacy between platelet-rich fibrin and platelet-rich plasma

• safety between platelet-rich fibrin and platelet-rich plasma Participants will be divided into 2 side of treatment with composed of

  1. Platelet rich plasma
  2. Platelet rich fibrin

Full description

Subject was treated both platelet-rich fibrin and platelet-rich plasma for 3 times which 1 month interval then will be followed up at 4 months and 6 months after last treatment

Enrollment: 10 estimated patients

Sex: Female

Ages: 20 to 55 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Age 20-55 years
• Female
• Subject who was diagnosed with Female pattern hair loss in Ludwig Classification 2 (part width 2-4 centimeters) by Dermatologist

Exclusion criteria

• Pregnancy or Lactation subjects
• Subject with history of platelet dysfunction, low platelet, anemia, cirrhosis, cancer, or immunocompromised host
• Subject who are active smoking and alcoholism
• Subject who has dermatitis, scar or infection at intervention area
• Subject who has history of allergy to anesthesia drug
• Subject who taking NSAIDs, Hormonal drug, anticoagulants drug
• Subject who has psychiatric condition diagnosed by psychiatrist
• Subject who are not allowed to take a photo

Trial design

Primary purpose: Treatment

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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10 participants in 1 patient group

PRF and PRP

Experimental group

Description:

All patients were treated with both platelet rich fibrin and platelet rich plasma but each side of head (left or right) was split with * one side of head was injected with platelet rich plasma at week 0,4 and 8 (total 3 times) * another side of head was injected with platelet rich fibrin at week 0,4 and 8 (total 3 times)

Treatment:

Device: Platelet rich plasma

Device: Platelet rich fibrin