The Efficacy and Safety of Pyramax in Mild to Moderate COVID-19 Patients

Shin Poong Pharmaceutical

Status and phase

Completed

Phase 2

Conditions

COVID-19

Treatments

Drug: Placebo

Drug: Pyronaridine-Artesunate

Study type

Interventional

Funder types

Industry

Identifiers

NCT04475107

SP-PA-COV-201

Details and patient eligibility

About

This study is a multi-center, randomized, double-blind, parallel, placebo-controlled, phase Ⅱ clinical trial to evaluate efficacy and safety of Pyramax in mild to moderate COVID-19 patients.

Enrollment

113 patients

Sex

All

Ages

19+ years old

Volunteers

No Healthy Volunteers

Inclusion criteria

Age ≥19 years at the time of signing Informed Consent Form
Body weight ≥45 kg at screening
Laboratory (rRT-PCR) confirmed infection with SARS-CoV-2 by testing specimens from upper airway (i.e. nasopharyngeal and oropharyngeal swab) or lower airway (i.e. sputum) within 96 hours of randomization
Oxygen saturation(SpO2) > 94% at randomization, in room air condition
Willing and able to provide informed consent

Exclusion criteria

Diagnosed with severe pneumonia
Patients with clinically significant cardiovascular disease (including arrhythmia, QTc interval prolongation)
Patients with clinically significant anemia (Hemoglobin <8.0 g/dL)
Patient with known allergic reaction or contraindication to any of the investigational medicinal product (pyronaridine tetraphosphate, artesunate)
Patients with known history of galactose intolerance, Lapp lactase deficiency or glucose-galactose malabsorption, etc.
Patients with the gastrointestinal disease and surgery to affect the absorption, distribution, metabolism and excretion of the drug, active gastritis, gastrointestinal tract / rectal bleeding, gastric ulcer, pancreatitis abnormalities (except simple appendectomy or hernia surgery)
Patients who received antiviral drugs that is intended to treat COVID-19, within 28 days prior to screening evaluation (can be enrolled into the study, if the patient has gone through a sufficient wash-out period)
Patients with known severe renal impairment (estimated glomerular filtration rate ≤30 mL/min/1.73 m2)
Patients with known severe liver disease (i.e. ALT or AST>5 times upper limit, nausea, abdominal pain associated with jaundice or Child-Pugh stage B or C)
Viral disease (HIV, HBV, HCV, etc.) other than COVID-19 that require administration of other antiviral agents
Patients that require ventilation therapy (e.g. non-invasive ventilation, invasive mechanical ventilation, extracorporeal membrane oxygenation, etc.)
Patients with chronic underlying disease (e.g. uncontrolled diabetes mellitus, chronic kidney disease, chronic liver disease, chronic pulmonary disease, chronic cardiovascular disease, blood cancer, cancer patients with cancer treatment, patients taking immunosuppressants), highly obese patients, dialysis patients, and transplant patients that are determined by the Physician, to be not suitable for trial involvement.
Pregnant or lactating women
Male or female of childbearing potential who has plans to become pregnant during the study period and for three months after the clinical study or who is not willing to take appropriate contraceptive measures

*Hormonal contraception (contraceptive implant, injections, pills, etc.), IUDs, condoms (male) and contraceptive diaphragm or cap (female), sterilization (vasectomy, tubal ligation, etc.)
Participating in another clinical trial currently or within 28 days from signing the informed consent
Patients that are deemed ineligible to participate in the clinical trial by the Investigator