The Efficacy and Safety of the Loading Dose of Tranexamic Acid in Scoliosis Surgery During Perioperative

Zhejiang University

Status: Completed

Conditions: Tranexamic Acid

Study type: Observational

Funder types: Other

Identifiers

NCT04952285

2021-0215

Details and patient eligibility

About

This study intends to make full use of the advantage of spinal orthopedic surgery in our medical center.Analyze the blood loss and blood coagulation function and the influence of safety of load dose tranexamic acid (TXA) in scoliosis surgery during perioperative.

Enrollment: 207 patients

Sex: All

Ages: 18 to 60 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• age:18-60 years old
• American Society of Anesthesiologists (ASA):I-II
• The spinal orthopedic undergoing elective surgery

Exclusion criteria

• Severe cardiopulmonary dysfunction
• Blood coagulation dysfunction
• Disorders of liver and kidney function
• Tranexamic acid allergies
• The history of pulmonary embolism and venous thrombosis of lower limbs
• Anticoagulant drugs and nonsteroidal anti-inflammatory drugs in 7 days

Trial design

207 participants in 2 patient groups

Normal saline（I）

Description:

Intravenous infusion of 0.9% saline when start to cut the skin，do not intravenous tranexamic acid during the surgery

Tranexamic acid（II）

Description:

Intravenous infusion of tranexamic acid 1g when start to cut the skin in 1 hour