The Efficacy of 1,064-nm Picosecond Laser With Microlens Array for the Treatment of Abdominal Striae Distensae

Mahidol University

Status: Unknown

Conditions: Striae Alba

Treatments: Device: fractional picosecond 1,064 nm laser

Study type: Interventional

Funder types: Other

Identifiers

NCT04456257

Si 591/2561

Details and patient eligibility

About

The objective of this study is to evaluate the efficacy and safety of a fractional 1,064 nm picosecond laser for the treatment of striae alba.

Full description

Striae distensae are atrophic dermal scars that can cause psychosocial distress on affected patients. Despite numerous available therapeutic modalities, no gold standard therapy has been established. Picosecond lasers are a newer advancement in lasers that have primarily used in the treatment of tattoos. A fractional 1064-nm picosecond laser has recently become available for the treatment of pigmentation and skin rejuvenation. The main mechanism of action is tissue ablation via laser induced optical breakdown (LIOB) which occur when pulse intensity is high enough to strip electrons and generating plasma, the plasma absorbs the remaining laser energy forming a cavitation bubble within the dermis which has been demonstrated to improve fine wrinkles and acne scar through the stimulation of collagen formation.

Enrollment: 12 estimated patients

Sex: Female

Ages: 18 to 60 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Striae alba on abdomen for more than 3 months
• Fitzpatrick skin type III-V

Exclusion criteria

• Pregnancy and breastfeeding
• Previous topical treatment, filler injection, chemical peel or laser treatment within 6 months before starting the study
• History of using Isotretinoin
• Photosensitive dermatoses, Infection, eczema
• Past history or family history of malignancy
• History of herpes infection
• History of hypertrophic scar or keloid, connective tissue disease
• History of collagen or elastin disease
• History of smoking
• Significant fluctuations in weight in the past 6 months

Trial design

Primary purpose: Treatment

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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12 participants in 1 patient group

Fractional Picosecond 1,064 nm laser

Experimental group

Description:

The subjects with abdominal striae alba were treated with a fractional picosecond 1,064 nm laser

Treatment:

Device: fractional picosecond 1,064 nm laser