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The Efficacy of Acupressure Therapy on Patient With Depression (Akupress)

U

University Psychiatric Clinics Basel

Status

Not yet enrolling

Conditions

Depressive Symptoms
Depressive Disorder, Major
Depressive Disorder

Treatments

Other: Acupressure

Study type

Interventional

Funder types

NETWORK

Identifiers

NCT05423405
Akupressur-Therapie

Details and patient eligibility

About

A new nursing intervention with non-invasive acupressure protocol for activation of parasympathetic nervous system to reduce stress related depression symptoms.

Full description

Acupressure is a treatment method in which manual pressure is applied to specific points or areas of the body. According to the principles of Traditional Chinese Medicine (TCM), these acupuncture points are stimulated along the energy channels (meridians) of the body. Finger pressure is mainly used here, in some cases also with a relaxing massage. According to TCM, this can stimulate the energy flow of the Qi. The therapist also tries to treat energetic blockages. Acupuncture is recommended for psychological problems, pain syndromes and sleep disorders, among other things.

Acupressure has been established as an additional therapy offer in private department J of the UPK since the beginning of 2021. Patients with depression and anxiety disorders subjectively benefit from the treatment in terms of reducing stress symptoms and improving relaxation.

Although patient acceptance is high, there are no high-quality studies on accompanying acupressure as part of standard treatments for depression, anxiety or sleep disorders. Their effectiveness in psychiatric patients is therefore controversial. Although there are few studies from "Western medicine" institutions, most of the clinical studies were carried out by Chinese colleagues. In most cases, only subjective assessment instruments were used to assess effectiveness without evaluating objective biomarker measurements such as cortisol concentration, brain-derived neurotrophic factor (BDNF) or cytokines.

A hypothesis on the effectiveness of acupressure in western medicine has not been established. The vagus nerve stimulation may play a role and thus the activation of the parasympathetic nervous system - which in turn could lead to a reduction in stress symptoms and an increase in relaxation and regeneration in the short and/or medium term. The role of the social bonding hormone oxytocin has not been studied so far.

The aim of this study is to evaluate the efficacy of acupressure adjunctive therapy in Major Depressive Disorder (MDD) as part of evidence-based treatment as usual (TAU) as a randomized, single-blind study.

Physiological and psychological assessment instruments should be used: cortisol levels in the saliva; serum oxytocin and BDNF levels; Heart rate variability, Hamilton Depression Rating Scale (HAM-D; third-party rating scale) and Beck Depression Inventory-II (BDI-II, self-rating scale).

The acupressure therapy protocol specially developed in the UPK could thus be established as a non-invasive, non-drug nursing therapy tool and achieve scientifically sound application in the UPK and other clinics, provided that proof of effectiveness is achieved.

We are pursuing a long-term strategy with our study because we are convinced that the current treatment options for depression are not sufficient and could be supplemented and improved by innovative and complementary therapies. Acupuncture can play a helpful role as an easily accessible and inexpensive method.

Enrollment

150 estimated patients

Sex

All

Ages

18 to 80 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

  • Age 18-80
  • Primary diagnosis of MDD with a current moderate-to-severe episode (HAM-D score > 16) 55
  • Treatment as usual for depression
  • Able to read and understand study procedures and participant's information
  • Agree to receive acupressure therapy

Exclusion criteria

  • Suicidal ideation
  • Antipsychotic medication
  • Primary diagnosis other than MDD
  • Contradiction for acupressure (skin diseases, pregnancy)

Trial design

Primary purpose

Supportive Care

Allocation

Randomized

Interventional model

Parallel Assignment

Masking

Double Blind

150 participants in 3 patient groups

control
No Intervention group
Description:
Treatment as usual with pharmacotherapy and other complementary therapies
Sham
Sham Comparator group
Description:
No actual acupoint pressed but same settings as in acupressure therapy
Treatment:
Other: Acupressure
Intervention
Experimental group
Description:
Treatment as usual plus acupressure intervention with selected acupoints pressure
Treatment:
Other: Acupressure

Trial contacts and locations

0

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Central trial contact

Regina Komminoth, MS; Hamdy Shaban, PhD

Data sourced from clinicaltrials.gov

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