The Efficacy Of Complete Mesocolic Excision With Central Vessel Ligation Technique On Lymph Nodes And Safety Margins Compared With Conventional Surgery For Colon Cancer Treatment

Assiut University

Status: Unknown

Conditions: Cancer Colon

Treatments: Procedure: Total Mesocolic Excision with Central Vessel Ligation; Procedure: conventional surgery of cancer colon

Study type: Interventional

Funder types: Other

Identifiers

NCT04079946

AssiutU93

Details and patient eligibility

About

Cancer Colon is one of the major public health problems worldwide. Complete eradication of the tumor with no recurrence or residual masses is a challenge which faces all the surgeons and medical staff all over the world. A lot of techniques were used to ensure 100 % eradication of the tumor and to cure the patients from cancer. Total Mesocolic Excision with Central Vessel Ligation is one of the recent techniques used for colon cancer surgeries. Here in the research the investigators answer the question of how this technique is superior and more beneficial in complete eradication of the tumor than the conventional surgery for colon cancer

Enrollment: 40 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• • Adult male and female Age of or above 18 years.

  • Tumor localization at the caecum, ascending colon, transverse colon, descending colon, sigmoid colon or rectosigmoid on preoperative endoscopy and radiographic imaging [barium enema or computed tomography (CT)]
  • No history of familial adenomatous polyposis, ulcerative colitis or Crohn's disease
  • Written informed consent

Exclusion criteria

• • Contraindications to major surgery and American Society of Anaesthesiologists (ASA) Physical Status scoring 4 which means extreme systemic disorders which have already become an eminent threat to life regardless of the type of treatment.

  • Infectious disease requiring treatment.
  • Pregnant women
  • Use of systemic steroids.
  • Severe pulmonary emphysema or pulmonary fibrosis

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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40 participants in 2 patient groups

patients for whom Complete mesocolic excision will be done

Active Comparator group

Treatment:

Procedure: Total Mesocolic Excision with Central Vessel Ligation

patients had conventional surgery before

Active Comparator group

Treatment:

Procedure: conventional surgery of cancer colon