The Efficacy of Dexmedetomidine Versus Labetalol In Providing Controlled Hypotension In Dacryocystorhinostomy SurgeryA Comparative Randomized Prospective Study

Sohag University

Status: Enrolling

Conditions: Nasolacrimal Duct Obstruction

Treatments: Drug: Labetalol; Drug: Dexmedetomidine

Study type: Interventional

Funder types: Other

Identifiers

NCT06346561

Soh-Med-24-02-10MS

Details and patient eligibility

About

The most important symptoms of nasolacrimal duct obstruction are excessive tearing and mucoid discharge.

The proposed treatment in this regard is dacryocystorhinostomy (DCR) surgery. Therefore, hemostasis is of great significance in performing DCR surgery. In this regard, the reduction of controlled hypotension and the control of hemodynamic responses of the body to stress effectively reduce the bleeding volume during surgery.

Hence, there is no enough studies about controlled hypotension in DCR we decided to perform such a comparison between the effect of dexmedetomidine and labetalol in providing controlled hypotension during DCR surgery.

Enrollment: 50 estimated patients

Sex: All

Ages: 18 to 60 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• physical status I or II according to ASA classification, age between ( 18 - 60 years )

Exclusion criteria

• Patients with physical status other than 1 and 2 according to ASA classification as :Hypertension, Diabetes mellitus, Ischemic heart diseases, Severe anemia, COPD, History of stroke, Impaired liver or renal function, Increase intercranial tension.
• Allergy to any of the drug included in this study.

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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50 participants in 2 patient groups

Dexmedetomidine group

Active Comparator group

Treatment:

Drug: Dexmedetomidine

Drug: Labetalol

Labetalol group

Active Comparator group

Treatment:

Drug: Dexmedetomidine

Drug: Labetalol