The Efficacy of Hyaluronic Acid and Honey in Healing of Multiple Extraction Sockets of Primary Teeth Compared to Saline

Cairo University (CU)

Status: Unknown

Conditions: Wound Heal

Treatments: Dietary Supplement: honey; Drug: Hyaluronic acid

Study type: Interventional

Funder types: Other

Identifiers

NCT05161403

wound healing on pediatric

Details and patient eligibility

About

This study aims to evaluate the effect of hyaluronic acid and honey compared to saline in healing of multiple extraction sockets of primary teeth in a group of children aging from Two to Seven years old.

Full description

A dental extraction is one of the most unpleasant experiences in children, especially for those who have undergone traumatic experiences, and this is likely to reduce future visits to the dental clinic if the treatment is not managed properly.

Alveolar osteitis is one of the most common complications following dental extraction. It is considered one of the most studied complications in dentistry, and many risk factors contribute to its occurrence including being a female, young age, tobacco use, difficult or traumatic extractions, pre-existing infection, and use of vasoconstrictor in local anesthesia. Alveolar osteitis occurs during the first three days following the day of extraction, so that the socket is devoid of the blood clot, resulting in the exposure of the bare alveolar bone.

Many medicines were and are still used in treating wounds, but they are somewhat expensive.

Enrollment: 39 estimated patients

Sex: All

Ages: 2 to 7 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• • Age: from Two to Seven years old age.

  • Both genders.
  • Children with badly decayed multiple primary teeth beyond repair.
  • Treated under general anesthesia.

Exclusion criteria

• • History of systemic disease.

  • Allergy to honey.
  • Repeatedly used honey during the previous 6 month period.

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

---

39 participants in 3 patient groups, including a placebo group

Hyaluronic acid.

Active Comparator group

Description:

1mm layer of hyaluronic acid on a piece of gauze will be applied directly to the sockets wound for 45 minutes at baseline and on the third \& seventh day after extraction of teeth.

Treatment:

Drug: Hyaluronic acid

Dietary Supplement: honey

Honey

Active Comparator group

Description:

1mm layer of Honey on a piece of gauze will be applied directly to the sockets wound for 45 minutes at baseline and on the third \& seventh day after extraction of teeth.

Treatment:

Drug: Hyaluronic acid

Dietary Supplement: honey

Saline

Placebo Comparator group

Description:

a piece of gauze moistened with normal saline will be applied directly to the sockets wound for 45 minutes at baseline and on the third \& seventh day after extraction of teeth.

Treatment:

Drug: Hyaluronic acid

Dietary Supplement: honey