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The Efficacy of Isocapnic Hyperpnoea to Accelerate Recovery After General Anesthesia With Sevoflurane

University Health Network, Toronto logo

University Health Network, Toronto

Status and phase

Completed
Phase 3

Conditions

Anesthesia

Treatments

Procedure: Isocapnic Hyperponea

Study type

Interventional

Funder types

Other

Identifiers

NCT00242671
UHN REB 05-0299-AE

Details and patient eligibility

About

The twilight phase between being asleep and awake during recovery from anesthesia is a precarious time fraught with risks to the post-operative patient. Hyperventilation accelerates the elimination of inhaled anesthetics but reduces their CO2 blood concentrations which delays their resumption of spontaneous breathing. We previously showed that our method of hyperventilation without affecting the CO2 concentration--which we call IH--accelerates the rate of emergence from anesthesia with isoflurane. In this study we will study the effect of IH on the rate of emergence from Sevoflurane anesthesia.

Sex

Female

Ages

18 to 80 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

  1. Elective gynecological procedure
  2. ASA I-III
  3. Age 18-80 years
  4. Signed informed consent

Exclusion criteria

  1. ASA IV
  2. Patients with contra-indications to Sevoflurane anesthesia or other anesthetics included in the protocol
  3. Active smoking, asthma or other history of hyper-reactive airway disease
  4. History of chronic obstructive lung disease limiting exercise
  5. History of angina, previous myocardial infarction, valvular heart disease, or heart surgery
  6. Presence of heart murmurs or neck bruits
  7. ECT abnormalities including atrial fibrillation, prolonged P-R interval, prolonged Q-T interval, presence of Q waves in inferior, anterior or lateral leads, criteria for left ventricular hypertrophy, T-wave abnormalities,
  8. History of difficult airway access
  9. Pulmonary hypertension and/or right ventricle dysfunction
  10. History of bulous emphysema, and/or spontaneous pneumothorax
  11. History of alcohol or drugs abuse
  12. Known history of psychiatric illness and/or medications
  13. Patients that required postoperative mechanical ventilation for any reason

Trial design

Primary purpose

Treatment

Allocation

Randomized

Interventional model

Parallel Assignment

Masking

Single Blind

Trial contacts and locations

1

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Data sourced from clinicaltrials.gov

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