The Efficacy of Nasal High Flow Oxygen Therapy With Rehabilitation in the Patients With Chronic Respiratory Failure

National Hospital Organization Minami Kyoto Hospital

Status: Completed

Conditions: Rehabilitation; Chronic Respiratory Failure; Exercise Endurance; Nasal High Flow Therapy

Treatments: Device: nasal high flow therapy

Study type: Interventional

Funder types: Other

Identifiers

NCT02804243

27-10

Details and patient eligibility

About

The purpose of this study is to compare the exercise endurance between oxygen therapy with rehabilitation and nasal high flow therapy with rehabilitation for the patients with chronic respiratory failure receiving long-term oxygen therapy.

Full description

In patients with chronic respiratory failure, pulmonary rehabilitation is recognized as an evidence-based treatment in improving exercise capacity, muscle strength, dyspnea, and quality of life. Oxygen supplementation during exercise induced dose-dependent improvement in endurance and symptom perception in chronic obstructive pulmonary disease patients. Recently, nasal high flow therapy which consists of high flow gas with an FiO2 ranging from 0.21 to nearly 1.0 adjusted by an oxygen blender, brought to body temperature, and saturated with water through an in-line humidifier is available.

The present study is randomised to compare the effect of exercise endurance between oxygen therapy with rehabilitation and nasal high flow therapy with rehabilitation for the patients with chronic respiratory failure receiving long-term oxygen therapy.

Enrollment: 32 patients

Sex: All

Ages: 20+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Subjects with chronic respiratory failure receiving long-term oxygen therapy for more than 3 months.

Exclusion criteria

• Subjects with severe cardiovascular disease, diabetes, neurological disease, and renal failure.
• Subject who are unable to undergo rehabilitation.

Trial design

Primary purpose: Other

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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32 participants in 2 patient groups

nasal high flow therapy

Active Comparator group

Description:

In this group, patients have undergone rehabilitation under the nasal high flow therapy (FiO2 100%, oxygen flow from 30 to 60 L/min) during four weeks.

Treatment:

Device: nasal high flow therapy

oxygen therapy

No Intervention group

Description:

In this group, patients have undergone rehabilitation under the oxygen therapy via a nasal canula (6 L/min) during four weeks.