The Efficacy of Oral Antiseptics Against COVID-19

Ataturk University

Status and phase: Completed; Phase 4

Conditions: COVID-19

Treatments: Drug: Hypochlorous Acid 0.02% Soln,Top (Crystaline) (HClO)

Study type: Interventional

Funder types: Other

Identifiers

NCT05214196

MIC1

Details and patient eligibility

About

In a study conducted on 75 COVID-19 patients, the effect of SARS-CoV-2 on viral load was investigated as a result of the use of hypochlorous acid and povidone-iodine as an oral antiseptic.

Full description

Before and 30 minutes after rinsing with mouth antiseptics, the participants were asked to rinse the mouth and throat for 30 seconds with 0.9% isotonic saline. The sample was sputtered into a sterile plastic container. The participants were grouped according to the type of oral antiseptics used. The effectiveness of SARS-CoV-2 viral load was investigated by rinsing the mouth and throat for 30 seconds with 20 ml of hypochlorous acid, povidone-iodine, and isotonic saline. Viral load was analyzed by RT-PCR analysis. The results were evaluated by statistical analysis.

Enrollment: 75 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Positive SARS-CoV-2 RT-PCR result,
• Adult hospitalized patient,
• The participants have the physical and psychological ability to follow the instructions in the study.

Exclusion criteria

• Patients intubated and supported by a mechanical respirator,
• Severe acute or chronic medical or psychiatric condition,
• History of significant adverse effects following use of oral hygiene products such as toothpaste and mouth rinses,
• Active uncontrolled thyroid disease,
• Developmental/cognitive disability,
• Pregnancy,
• Undergoing radioactive iodine therapy.

Trial design

Primary purpose: Supportive Care

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Triple Blind

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75 participants in 3 patient groups, including a placebo group

Hypochlorous acid group

Experimental group

Description:

The effect of 0.02% Hypochlorous acid solution on viral load was investigated by using 25 COVID-19 patients as an oral antiseptic for 30 seconds.

Treatment:

Drug: Hypochlorous Acid 0.02% Soln,Top (Crystaline) (HClO)

Povidone-iodine group

Active Comparator group

Description:

The effect on viral load was investigated by using 0.5% Povidone-iodine solution as an oral antiseptic for 30 seconds in 25 COVID-19 patients.

Treatment:

Drug: Hypochlorous Acid 0.02% Soln,Top (Crystaline) (HClO)

Saline group

Placebo Comparator group

Description:

The effect on viral load was investigated by using 0.9% isotonic saline solution as a placebo for 30 seconds in 25 COVID-19 patients.

Treatment:

Drug: Hypochlorous Acid 0.02% Soln,Top (Crystaline) (HClO)