The Efficacy of Oral Versus Intravenous Hypertonic Saline Administration in Runners With Exercise-Associated Hyponatremia

Western States Endurance Run Research Foundation

Status: Unknown

Conditions: Exercise-associated Hyponatremia

Treatments: Other: Intravenous hypertonic Saline; Other: Oral hypertonic saline

Study type: Interventional

Funder types: Other

Identifiers

NCT01110655

WSER 2009

Details and patient eligibility

About

The purpose of the study is to 1) evaluate incidence and primary cause of exercise-associated Hyponatremia (EAH) in race finishers participating in the Western States 100-mile Endurance Run, 2) determine if the ingestion of oral hypertonic saline (high salt) is as effective as intravenous administration of hypertonic saline to elevate below-normal blood salt concentrations (EAH) at the end of the Western States Endurance Run, and 3) determine if oral and intravenous hypertonic saline solutions are equally as effective at reversing mild (without altered mental status) symptoms associated with EAH.

Enrollment: 100 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• consenting Western States 100 race finisher
• hyponatremic

Exclusion criteria

• altered mental status

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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100 participants in 2 patient groups

Intravenous hypertonic saline

Experimental group

Treatment:

Other: Intravenous hypertonic Saline

Oral hypertonic saline

Experimental group

Treatment:

Other: Oral hypertonic saline