The Efficacy of Scaling and Root Planing on Endothelin-1 Level (clinical)

University of Baghdad

Status: Not yet enrolling

Conditions: Periodontitis

Treatments: Device: Scaling and root surface debritment

Study type: Interventional

Funder types: Other

Identifiers

NCT06784869

1/10/2024

Details and patient eligibility

About

Periodontitis is a chronic inflammatory disease resulting from bacterial invasion. Endothelin (ET-1) is a potent vasoconstrictor critical in the pathophysiology of periodontal diseases.

Aim The present study aimed to measure the ET-1 concentrations in gingival crevicular fluid (GCF) at baseline, one and three months subsequently to non-surgical periodontal therapy.

Material and methods Designed as a clinical trial, 24 periodontitis individuals will be voluntarily consented to participate. Following non-surgical periodontal treatment, GCF samples will be collected to determine the amount of endothelin-1 at baseline, one, and three months. Clinical periodontal parameters will be recorded.

Full description

Periodontitis is a chronic inflammatory disease resulting from bacterial invasion. Endothelin (ET-1) is a potent vasoconstrictor critical in the pathophysiology of periodontal diseases.

Aim The present study aimed to measure the ET-1 concentrations in gingival crevicular fluid (GCF) at baseline, one and three months subsequently to non-surgical periodontal therapy.

Material and methods Designed as a clinical trial, 24 periodontitis individuals will be voluntarily consented to participate. Following non-surgical periodontal treatment, GCF samples will be collected to determine the amount of endothelin-1 at baseline, one, and three months. Clinical periodontal parameters will be recorded.

Enrollment: 24 estimated patients

Sex: All

Volunteers: No Healthy Volunteers

Inclusion criteria

• systemically healthy
• Generalized unstable periodontitis with a moderately deep pocket (4,5 or 6 mm)

Exclusion criteria

• subjects who wore dental prosthesis
• teeth with grade II mobility,
• alcoholic and smoker, had treated caries
• underwent periodontal therapy within the last four months

Trial design

Primary purpose: Treatment

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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24 participants in 1 patient group

have generalized unstable periodontitis with a moderately deep pocket (4,5 or 6 mm).

Experimental group

Description:

got generalized unstable periodontitis with a moderately deep pocket (4,5 or 6 mm) will undergo scaling and root surface debritment

Treatment:

Device: Scaling and root surface debritment