The Efficacy of Speech Competition Training on Auditory Hallucination in Schizophrenia

Jing SHI

Status: Enrolling

Conditions: Auditory Hallucination

Treatments: Other: speech competition training; Other: the soothing music

Study type: Interventional

Funder types: Other

Identifiers

NCT05850923

AH-IA-2021

Details and patient eligibility

About

One hundred schizophrenia patients with auditory hallucinations will be recruited and randomized into group A and group B. Participants of group A will firstly receive a speech competition training for 2 weeks, and those in group B will firstly receive music intervention as placebo treatment. Specifically, speech competition training include voice competition training twice a day in adjunction with drug treatment, and the patients will be required to perform voice-related tasks according to the instruction. The reaction time, accuracy rate and the number of auditory hallucinations during the task will be recorded. On the other hand, the placebo treatment includes soothing music twice a day for a fixed period of time while patients receiving drug treatment. After 2 weeks, the interventions for group A and group B will be switch.

Clinical symptoms will be evaluated using the auditory hallucinations rating scale, positive and negative syndrome scale, belief about voices questionnaire-revised at baseline, 2-week follow up and 4-week follow up. All the data will be analyzed with the Statistical Product and Service Solutions(SPSS) software.

Enrollment: 100 estimated patients

Sex: All

Ages: 18 to 55 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Fulfilling the diagnostic criteria for schizophrenia as in the International Classification of Diseases (ICD) - 10;
• Aged 18-55 years old;
• Education level over 6 years;
• The score of P3 item in PANSS ≥ 3 points;
• Taking antipsychotics at a therapeutic dose for at least 1 month, and the symptoms of auditory hallucinations have not been significantly improved, and the score of Auditory Hallucinations Rating Scale (AHRS) is still greater than 18 points;
• Capable of understanding and singing a written informed consent form, and be able to cooperate in completing intervention training and assessments.

Exclusion criteria

• Diagnosing other Axis I mental disorders;
• A history of severe neurological disease, brain trauma, major physical disease or history of drug dependence;
• Auditory hallucinations caused by organic brain diseases;
• Patients who cannot cooperate with the completion of training;
• Patients with serious suicidal or self injurious behavior;
• Pregnant and lactating women;
• History of alcohol abuse;
• Intellectual impairment (IQ<70);
• Patients with hearing impairment.

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: Single Blind

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100 participants in 2 patient groups

a speech competition experimental group

Experimental group

Description:

The speech competition training was arranged twice a day, each lasting 15 minutes. The training included word search in sequence, word search out of order and word sorting. Patients need to follow the instructions in time for training. The reaction time, accuracy rate and the number of auditory hallucinations during the task were recorded.

Treatment:

Other: speech competition training

Control group

Active Comparator group

Description:

The patient will listen to the soothing music twice a day, each lasting 15 minutes.

Treatment:

Other: the soothing music