The Efficacy of Steroid Therapy in Vestibular Neuritis

Asan Medical Center

Status and phase: Completed; Phase 3

Conditions: Vestibular Neuritis

Treatments: Drug: Ginkgo biloba; Drug: Ginkgo biloba & Methylprednisolone

Study type: Interventional

Funder types: Other

Identifiers

NCT02098330

SVNHIT_kr

Details and patient eligibility

About

The purpose of this study was to compare the treatment effectiveness of steroid therapy for vestibular neuritis by using video head impulse test.

Full description

This study was a prospective, randomized controlled study. The enrolled vestibular neuritis patients were randomized to conservative treatment or steroid treatment when they are diagnosed with caloric test. After initial vestibular work-up including caloric, video head impulse tests, and a questinnaire (DHI), the patient was examined with the same tests again at 6 months later. The efficacy of steroid for the patients with vestibular neuritis would be determined by the comparison of the data of each group.

Enrollment: 40 patients

Sex: All

Ages: 18 to 80 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Ages over 18 years
• Acute vertigo that occurred within 7 days
• The spontaneous nystagmus should be detected
• Caloric weakness over 20%

Exclusion criteria

• Suspicious or verified a central nervous system lesion
• If the patient has denied.
• Other otologic disease (acute/chronic otitis media, otosclerosis, etc)
• The patient with history of otologic surgery
• The patient with history of brain surgery

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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40 participants in 2 patient groups, including a placebo group

: Ginkgo biloba & methylprednisolone

Active Comparator group

Description:

Patients receive Ginkgo biloba \& methylprednisolone per oral.

Treatment:

Drug: Ginkgo biloba & Methylprednisolone

Ginkgo biloba

Placebo Comparator group

Description:

Patients receive Ginkgo biloba per oral.

Treatment:

Drug: Ginkgo biloba