The Efficacy of Topical Sesame Oil Versus Topical Triamcinolone on Oral Lichen Planus and Salivary Level of Oxidative Stress Biomarker [MDA] ((MDA))

Mona Taha Mohammed MD

Status and phase: Unknown; Early Phase 1

Conditions: Oral Lichen Planus

Treatments: Drug: Sesame Oil; Drug: triamcinolone in orabase

Study type: Interventional

Funder types: Other

Identifiers

NCT03738176

2:5:1

Details and patient eligibility

About

use seseme oil and corticosteroid topically for two groups

Full description

• The enrolled patients will be divided randomly into two groups.
• Test group will receive topical sesame oil (3 times /day after eating) for a month.
• Control group will receive topical corticosteroid (3 times /day after eating) for a month.
• Assessment of the appearance score and severity of pain as well as the clinical parameter outcome will be done at baseline and at the end of two and four weeks and will be recorded in the patients' questionnaires & by clinical sign score . MDA will be measured at the baseline & at the end of four weeks after treatment.

Enrollment: 40 estimated patients

Sex: All

Ages: 18 to 80 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients who will be clinically diagnosed as having atrophic &/or erosive oral lichen planus.

  • Patients with no history of taking topical corticosteroids for the last 2 months and systemic corticosteroid for the last 6 months
  • Patients who agree to take medication and follow up .

Exclusion criteria

• Pregnant and lactating ladies.

  • Patients with history of topical steroids during last 2 months & systemic steroids during last 6 months.
  • Patients with recent dental filling associated with the lesion or associated with recent drug administration.
  • Patient with history of diabetes or hypertension or those with positive HCV ab or HBs Ag.

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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40 participants in 2 patient groups

sesame oil in orabase

Experimental group

Description:

20 gm sesame oil-80 gm CMC 3 times per day for one month

Treatment:

Drug: Sesame Oil

triamcinolone in orabase

Active Comparator group

Description:

140 gm triamcinolone-50 gm Na CMC 3 times per day for one month

Treatment:

Drug: triamcinolone in orabase