The Efficacy of Trimethoprim in Wound Healing of Patients With Epidermolysis Bullosa

The Hospital for Sick Children

Status and phase

Completed

Phase 2

Conditions

Epidermolysis Bullosa

Treatments

Drug: Trimethoprim

Study type

Interventional

Funder types

Other

Identifiers

NCT00380640

1000009064

Details and patient eligibility

About

The purpose of this study is to assess the efficacy of trimethoprim in promoting wound healing and decreasing blister formation in patients with Epidermolysis Bullosa.

Full description

Epidermolysis Bullosa (EB) comprises a series of hereditary disorders characterized by fragility of the skin and mucous membranes and the tendency of the skin to blister in response to minor friction or trauma. The care of patients with EB is a complex task that has to be carried out by a multi-professional team. In the absence of a cure, the goal of therapy is the prevention and healing of chronic wounds.

In patients with EB, chronic inflammation interferes with proper wound healing. One treatment option is the use of anti-inflammatory antimicrobial agents, such as trimethoprim, to hasten wound healing and decrease blister formation. This treatment may lead to decreased pain and improvement of the quality of life for these patients.

Enrollment

10 patients

Sex

All

Ages

1 day to 20 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

Patients younger than 20 years of age
Diagnosis of Recessive Dystrophic Epidermis Bullosa (RDEB)or Junctional Epidermis Bullosa (JEB)
Signed consent/assent form

Exclusion criteria

-Previous known allergy or intolerance to trimethoprim