The Efficiency of HHHFNC Between Unheated Oxygen Therapy in Difficult Weaning Patients After Extubation in RCC

Shin Kong Wu Ho-Su Memorial Hospital

Status: Completed

Conditions: Critically Illness

Treatments: Device: Heated Humidified High-Flow Nasal Cannula

Study type: Interventional

Funder types: Other

Identifiers

NCT04564859

SKH-8302-106-NDR-05

Details and patient eligibility

About

The purpose of this study is to assess the efficacy of Heated Humidified High-Flow Nasal Cannula compared with noninvasive positive-pressure ventilation in the prevention of extubation failure in patients with prolonged mechanical ventilation.

Full description

There have been many clinical trials comparing the role of Heated Humidified High-Flow Nasal Cannula or Noninvasive positive pressure ventilation in the prevention of extubation failure.

These review all have similar results summarized here:

Compared with Noninvasive positive pressure ventilation, Heated Humidified High-Flow Nasal Cannula provides better patient comfort, fewer oxygen desaturation episodes, lower likelihood of interface displacement, and, lower reintubation rate than Noninvasive positive pressure ventilation.

However, most of these clinical trials focused on participants experiencing acute respiratory failure.

Investigators of this study want to find something difference between oh these two groups.

Enrollment: 80 patients

Sex: All

Ages: 20 to 100 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Age: Over 20 years of age
• the requirement of at least six hours of mechanical ventilation per day for at least 14 consecutive days

Exclusion criteria

• Pregnancy
• Status post tracheostomy
• Neuromuscular diseases
• Signed "do not resuscitate" order
• Unplanned extubation

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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80 participants in 2 patient groups

Noninvasive Ventilation group

Experimental group

Description:

Noninvasive Ventilation group initial setting： Insp. Pressure：12 \~ 16 centimeter of water Exp. Pressure ： 4 \~ 6 centimeter of water FiO2：Keep oxygen saturation measured by pulse oximeter：\> 92% By condition, gradually tap 2\~3 centimeter of water inspiratory positive airway pressure Keep Tidal volume：6\~10 ml/kg

Treatment:

Device: Heated Humidified High-Flow Nasal Cannula

Heated Humidified High-Flow Nasal Cannula group

Active Comparator group

Description:

Heated Humidified High-Flow Nasal Cannula group initial setting： Flow setting: 50 L/m FiO2：Keep oxygen saturation measured by pulse oximeter \> 92% temperature:37 ℃ By condition, gradually tap Flow 5 L/m

Treatment:

Device: Heated Humidified High-Flow Nasal Cannula