The ENDOCARDITIS AUMC Data Collection (ENDO_AUMC)

Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)

Status: Enrolling

Conditions: Coagulation Disorder; Endocarditis; Valve Disease, Heart

Treatments: Other: None, observational

Study type: Observational

Funder types: Other

Identifiers

NCT05139589

W21_466#21.518

Details and patient eligibility

About

The investigators will compare patients with and without infective ndocarditis undergoing valve surgery and evaluate factors that may help optimise perioperative care of these high-risk patients.

Full description

The aim of this study is to examine the differences between patients with and without endocarditis who undergo cardiothoracic (valve) surgery. In addition, the investigators will look at the differences between endocarditis patients who undergo surgery, and those who are treated conservatively. The investigators will look at incidence and degree of perioperative coagulation abnormalities, as well as transfusion and coagulation factor requirements, heparin resistance, bleeding scores, predictive endocarditis mortality scores, vasopressor-inotrope scores, and relate these where possible to the pathogen causing IE. The investigators will also look at perioperative complications, in particular, thromboembolic events and mortality at 30 and 90 days, and at 1 year.

These outcomes may help optimise perioperative care for high-risk endocarditis patients, and in particular those undergoing valve surgery.

Enrollment: 3,000 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients > 18 years
• Dutch or English speaking
• All patients with infective endocarditis admitted to Amsterdam UMC in the study period
• All patients with infective endocarditis scheduled for cardiac valve surgery compared to a matched cohort of patients scheduled for similar surgery due to non-infectious indication in Amsterdam UMC in the same period

Exclusion criteria

• Previous history of coagulation disorders

Trial design

3,000 participants in 3 patient groups

Infective endocarditis, surgical arm

Description:

Patients with infective endocardits requiring valve surgery

Treatment:

Other: None, observational

Infective endocarditis, conservative arm

Description:

Patients with infective endocardits, not requiring valve surgery

Treatment:

Other: None, observational

Valve disease, heart, surgically repaired

Description:

Patients requiring valve surgery

Treatment:

Other: None, observational