The Epigenetics of Exercise and Physical Activity in COPD

Veterans Affairs (VA) Boston Healthcare System

Status: Unknown

Conditions: Copd

Study type: Observational

Funder types: Other U.S. Federal agency

Identifiers

NCT03539042

3013

Details and patient eligibility

About

This study seeks to examine genome-wide DNA methylation patterns associated with physical activity and exercise capacity from peripheral blood collected from participants with chronic obstructive pulmonary disease (COPD) before and after participation in a structured 9-week outpatient pulmonary rehabilitation program.

Full description

Individuals who are referred to pulmonary rehabilitation IN THE COURSE OF THEIR USUAL CLINICAL CARE will be invited to participate in this observational study. Participants who enroll in the study will undergo two in-person visits, once before initiating pulmonary rehabilitation classes and once at the conclusion of pulmonary rehabilitation classes. Participation in this study will not alter the course of the participants' usual clinical care.

Enrollment: 50 estimated patients

Sex: All

Ages: 40+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Age >40 years
• Diagnosis of COPD (defined as an FEV1/FVC<0.7 or evidence of emphysema on radiologist's read of a chest CT obtained in the course of patient's usual care)
• Referral to and participation in the VA Boston Pulmonary Rehabilitation program

Exclusion criteria

• Active or unstable cardiac disease
• Inability to ambulate > 1 block
• Recent acute exacerbation of COPD (defined as new or increased dose of systemic steroids and/or antibiotics for pulmonary indications)