The Evaluation for Prognostic Factors After Catheter Ablation of Atrial Fibrillation: Cohort Study

Yonsei University

Status: Enrolling

Conditions: Atrial Fibrillation

Study type: Observational

Funder types: Other

Identifiers

NCT02138695

4-2014-0104

Details and patient eligibility

About

1. Purpose of the study

1. To explore clinical recurrence associated clinical factors including age, sex, clinical, electrophysiological, anatomical, imaging, and serologic characteristics.

2. To develop simulation model to predict clinical recurrence and the efficacy of catheter ablation 2. Scientific evidence of the study

1. In atrial fibrillation patients, the maintenance of normal sinus rhythm showed significant reduction of mortality.

2. drug therapy with anti-arrhythmic drug showed many complications and side effect, thus non-drug therapy such as catheter ablation is developed.

3. catheter ablation has been performed for 10years world-wide, and showed superior treatment outcome compared with drug therapy.

4. clinical outcome after catheter ablation is affected not only by age, sex and underlying disease, but also by electrophysiologic, imaging, serologic and electroanatomical remodeling of the heart. However, there are few studies concerning these multifactorial variables.

5. Study population

Enrollment: 3,100 estimated patients

Sex: All

Ages: 19+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• patients who undergoing catheter ablation of atrial fibrillation due to symptomatic, drug refractory atrial fibrillation

Exclusion criteria

• patients who do not agree with study inclusion
• permanent AF refractory to electrical cardioversion
• AF with valvular disease ≥ grade 2
• patients with left atrial diameter greater than 60mm
• patients with age less than 19

Trial design

3,100 participants in 1 patient group

Yonsei AF Cohort

Description:

Patients with atrial fibrillation who undergoing catheter ablation of atrial fibrillation