The Evaluation of Left Ventricular Systolic Function in Different Types of Ischemic Heart Disease

Peking University

Status

Completed

Conditions

Obstructive Coronary Heart Disease

Coronary Microvascular Dysfunction

Treatments

Diagnostic Test: Two dimensional speckle tracking imaging

Study type

Observational

Funder types

Other

Identifiers

NCT04959357

048-01

Details and patient eligibility

About

The study was designed to evaluate the left ventricular longitudinal strain and strain rate assessed by 2D-STI in patients with coronary microvascular dysfunction (CMD) or obstructive coronary artery disease (CAD) , to investigate the effect of different types of ischemic heart disease on the LV systolic function, and to explore the value of LS on the diagnosis of coronary microvascular dysfunction.

Full description

A total of 175 patients with chest pain, without wall motion abnormality and without significant coronary artery stenosis (<50%) assessed by coronary angiography or coronary computed tomography were enrolled from July 2011 to December 2017. Coronary flow reserve (CFR) of these patients were detected by transthoracic Doppler echocardiography. The patients were divided into coronary microvascular dysfunction group ( CFR≤2.5, n=67) and control group (CFR>2.5, n=108). At the same time, 67 age-matched patients with any major coronary arteries stenosis≥50% and without wall motion abnormality were involved into the obstructive coronary artery disease group. Parameters of global longitudinal strain (LS) and strain rate, subendocardial LS and subepicardial LS were quantified by 2D-STI, the differences of these parameters among three groups were analyzed，correlation analysis、univariate and multivariate analysis and receiver operating characteristic curve were used.

Enrollment

242 patients

Sex

All

Ages

18 to 85 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

age from 18-85 years

Exclusion criteria

patients with history of myocardial infarction or abnormal wall motion suggested by conventional echocardiography
patients with acute heart failure, chronic heart failure or LVEF values less than 50%
patients with congenital heart disease, severe valvular disease, severe bradycardia, high atrioventricular block and atrial fibrillation
patients who did not store ultrasound images or whose ultrasound images were unclear
patients who had incomplete clinical data