The EVLW for Set the Positive End Expiratory Pressure (PEEP) in the Acute Respiratory Distress Syndrome (ARDS)

University Hospital, Strasbourg, France

Status: Withdrawn

Conditions: Acute Respiratory Distress Syndrome

Study type: Observational

Funder types: Other

Identifiers

NCT00714987

3800

Details and patient eligibility

About

• ARDS is a severe pathology with high mortality and morbidity.Actual ventilatory management is clear for the set of the tidal volume and for the survey of the plateau pressure for the patients who require mechanical ventilation.
• The set of the PEEP (low or high levels) remains unclear : it seems that some patients need low levels of PEEP whereas anther need high levels; but there is no validated data that can discriminate them.
• We hypothesized that patients with low levels of EVLW ( measured with the Picco® system ) need low level of PEEP to ameliorate their oxygenation ( measured with the PaO2/FiO2 ratio ) whereas patients with high levels of EVLW) need high levels of PEEP.

Enrollment: 40 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• age>18;
• ARDS criteria.

Exclusion criteria

• severe pulmonary hypertension;
• chronic right ventricular failure;
• pulmonary embolism;
• tricuspidian valvulopathy;
• history of spontaneous pneumothorax;
• severe emphysema;
• bronchomalacia;
• recent pulmonary surgery;
• BMI>40;
• Interstitial pulmonary fibrosis;
• End of life;
• Chronic neuromyopathie;
• Recent neurosurgery or intracranian hypertension;
• Pregnancy.

Trial design

40 participants in 2 patient groups

1: High level PEEP

2: Low level PEEP